Soft Tissue 2.0

Question 1

Choristomas vs hamartoma

Answer 1

• Choristomas:
  
  • normal tissue in abnormal location
• Hamartoma:
  
  • excess tissue in normal location

Question 2

Rhabdomyosarcoma

Answer 2

• Types:
  
  • Embryonal (<10 y.o.)
    
    • loss of:
      
      • heterozygosity
        
        • imprinting at 11q15.5
  • Alveolar (10-25 y.o.)
    
    • PAX3 on chromosome 2
      
      • and FOXO1 on chromosome 13
    • PAX7 on chromosome 1
      
      • and FOXO1 on chromosome 13
  • Pleomorphic: (>40 y.o.)

Question 3

Kaposi Sarcoma

Answer 3

• HHV-8

Question 4

Angiosarcoma

Answer 4

• Scalp and forehead=common
  
  • early-resemble bruise
• Oral lesions=rare
  
  • tongue
  • mandible

Question 5

Congenital Epulis

Answer 5

• Present at birth
• FEMALES 100%

Question 6

Granular Cell Tumor

Answer 6

• Tongue=⅓ of cases
• Schwann cell origin

Question 7

Paraganglioma

Answer 7

• arise from paraganglia
  
  • autonomic nerves & ganglia
• Types: Based on location where they are found
  
  • Carotid Body Paragangliomas
    
    • carotid body tumors
    • Upper neck below angle of jaw
    • Fontaine’s sign-moves side to side but not vertical
  • Jugular Paragangliomas
    
    • glomius jugular tumors
    • middle ear or external auditory canal
  • Tympanic paragangliomas
    
    • Arnolds N.
    • Jacksons Nerve
• Histo:
  
  • Zellballen