Soft Tissue Translocations Flashcards
(26 cards)
Myxoid liposarcoma
t(12;16) (q13;p11)
FUS/CHOP (now called DDIT3)
90%
Myxoid liposarcoma
t(12;16)
(q13;p11)
FUS/CHOP (now called DDIT3)
90%
Chondroid lipoma
Hibernoma
t(11;16)
LG fibromyxoid sarcoma
t(7;16)
FUS/CREB3L2
Alveolar rhabdomyosarc (2)
t(2;13) PAX3-FKHR (now FOXO1)
t(1;13) PAX7-FKHR (now FOXO1)
Alveolar soft part sarcoma
t(x;17)
GCTs are associ. with what mutations?
CSF1
DSRCT
Translocation?
IHC profile?
Vimentin parttern?
t(11;22)
(p13;q12)
EWS-WT1
vim+ (perinuclear dot)
CK+
EMA+
WT+
Chondroid lipoma
Hibernoma
t(11;16)
q13;p13
Alveolar rhabdomyosarc (2)
- Myogenin vs. embryonal?
- prognosis vs. embryonal?
t(2;13) PAX3-FKHR (now FOXO1)**
t(1;13) PAX7-FKHR
- Greater myogenin expression
- worse prognosis
GCTs are associ. with what mutations?
Target for tx?
CSF1
Rank ligand
Intrasmucular myxomas
Syndromes?
GNAS1 point mutations
encodes for a G-protein leads to cAMP production
McCune-Albright
Mazabraud
Non-syndromic
ES myxoid chondrosarc
t(9;22)
q22;q12
Well-diff LS
MDM2
Clear cell sarc
t(12;22)
q13;q12
LG fibromyxoid sarcoma
Unique IHC?
t(7;16)
FUS/CREB3L2
MUC4 (highly sens and spec)
Alveolar soft part sarcoma
t(x;17) (p11;q25)
TFE3 gene on Xp11
Clear cell sarc
*How do they differ from PEComas?
t(12;22) (q13;q12)
*No myo-differention
SFT associated with what paraneoplastic syndrome?
What’s the syndrome called?
Hypoglycemia 2/2 ILFG
aka Doege-Potter syndrome
Angiomatoid fibrous histiocytoma
EWSR1-CREB1 now MC
- old = EWSR1-ATF1
- old = FUS-ATF1
Lipomas
12q13-15 (66%)
Spindle cell lipomas
Mammary-type myofibroblastoma
Cellular angiofibroma
13q14-22
Decreased Rb expression
Synonyms for INI-1
hSNF5
SMARCB
BAF47
IHC for epithelioid sarcomas
loss of INI-1 *like ATRT/Rhabdoid tumors
