Soft Tissue Tumors (Pathology)

Question 1

7 yo child
large swelling increasing over 3 yrs
circumscribed, lobular/nonencapsulated mass
mature adipose tissue w/small vessels

Answer 1

lipoma

Question 2

lipoblast

Answer 2

bad - seen in liposarcomas. bizzarre nucleus, vesicles of lipid

Question 3

53 yo man fast growing (6 wks) mass. biopsy shows very cellular tissue with atypical cells and a lipoblast

Answer 3

liposarcoma

Question 4

rapidly growing small, benign fibrous proliferation on subcutis, flexor aspects of arms in young adults. Rapid growth, painful.

Answer 4

nodular fasciitis

reactive proliferation

Question 5

After blunt trauma, mass in lower limb.

Shows well formed woven bone at periphery, but immature bone at center (meaning?)

Answer 5

Myositis Ossificans

means not malignant

Question 6

contracture in hand, often bilateral

Answer 6

superficial fibromatosis

Question 7

contracture in penis

Answer 7

peyronie disease

Question 8

contracture of plantar surface of feet

Answer 8

Ledderhose disease

Question 9

pediatric, female predominance, extra-abdominal mass.

Answer 9

deep fibromatosis

Question 10

adult fibromatosis gender preference

Answer 10

none (keloids)

Question 11

microscopic appearance of fibromatosis

Answer 11

bland cells, no mitotic figures, no necrosis

Question 12

tumore of mesenchmal origin. malignant fibroblasts on collagen background. herringbone.

Answer 12

fibrosarcoma

Question 13

age of fibrosarcoma of bone

Answer 13

any, but Dx in 4th decade

Question 14

location of fibrosarcoma of bone

Answer 14

tibia and femur

Question 15

35-55 yo soft tissue of thigh & posterior knee. large, painless mass deep to fascia with ill-defined margin.

Answer 15

soft tissue fibrosarcoma

Question 16

prognosis of adult fibrosarcoma of soft tissue

Answer 16

bad

Question 17

prognosis of infantile fibrosarcoma of soft tissue

Answer 17

good

Question 18

non-cancerous growth of dermal histiocytic cells. legs & arms, persists for years, firm nodules, tethered to underlying fibrous tissue

Answer 18

dermatofibroma

Question 19

bigger dermal mass invading deeper subcutaneous tissue

Answer 19

dermatofibrosarcoma protuberans (DFSP)

Question 20

cellular origin of dermatofibrosarcoma protuberans

Answer 20

unclear. capacity to differentiate into all 3 cell types, so maybe pluripotent

Question 21

most common soft-tissue sarcoma in late adult life

Answer 21

malignant fibrous histiocytoma

Question 22

spread of mets from sarcomas

Answer 22

hematogenous (lungs!)

Question 23

most important prognostic factor for malignant fibrous histiocytoma

Answer 23

clinical stage

Question 24

fish flesh

Answer 24

rhabdomyosarcoma

Question 25

muscle cell tumor

Answer 25

rhabdomyosarcoma

Question 26

age of rhabdomyosarcoma

Answer 26

children <10 2/3

Question 27

cell types in rhabdomyocarcoma

Answer 27

rhabdomyoblasts

Question 28

most common locations of rhabdomyosarcoma (6)

Answer 28

``` base of skull around eye head/neck/nose/throat arms/legs urinary system reproductive organs ```

Question 29

cell types in rhabdomyosarcoma

Answer 29

strap cells - elongated, may resemble muscle w/cross striations

Question 30

benign uterine tumor

Answer 30

leiomyoma

Question 31

cell types in leioma

Answer 31

cigar-shaped cells, no mitotic figures, no nuclear atypia. May be large zones of ischemic necrosis or degenerative change.

Question 32

uterine mass with hemorrhagic necrosis

Answer 32

leiomyosarcoma

Question 33

survival indicators for leiomyosarcoma

Answer 33

clinical stage, then histological grade

Question 34

cell types in leiomyosarcoma

Answer 34

cigar-shaped cells & many mitotic figures.

Question 35

mets of leiomyosarcoma

Answer 35

lung, hematogenous - cause of mortality