Specific drug toxicity Flashcards Preview

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Flashcards in Specific drug toxicity Deck (10):
1

doxorubicin

Dysrhythmias
Cardiomyopathy (DCM) - Give over 20-30 min, Monitor by echo., Care if pre-existing Dz, Risk increases at cumulative doses >180mg/m2
Mast cell degranulation
GI (colitis)
Vesicant if perivascular
Cats - ?nephrotoxic

2

Cyclophosphamide

Haemorrhagic cystitis

3

Cyclophosphamide - prevention of side effects

Monitor
Free access to water
Opportunity to urinate
Furosemide with high doses
Avoid prolonged courses

4

Cyclophosphamide - treatment of side effects

Analgesia
Oxybutinin
DMSO

5

vincristine

Peripheral neuropathies
Ileus (abdominal pain)
Constipation – Metoclopramide / ranitidine
Skin sloughs if perivascular injection

6

lomustine

Hepatotoxic – monitor ALT, SAMe
Potentially nephrotoxic – monitor renal function (SG) and dipstick for glucosuria

7

platinum drugs

Cisplatin is nephrotoxic
Carboplatin is preferable
Nausea via CTZ
cats - Cisplatin causes fatal pulmonary oedema, 5-FU causes neurotoxicity

8

herding breeds

Collies, Shelties, Australian Shepherd, LH Whippets can have increased susceptibility to vincristine and doxorubicin due to mutated MDR1 gene
Poor drug excretion
PCR test

9

prednisolone

PD, PU, PP, panting, muscle weakness,
slow healing, immunosuppression

10

L-asparaginase

Possible anaphylactic reactions