Spleen

Question 1

What other organs are involved in lymphocyte production

Answer 1

Lymph nodes, thymus and bone marrow

Question 2

Which is the largest lymphatic organs

Answer 2

Spleen

Question 3

The spleen and which other issue is involved in hematopoesis

Answer 3

Bone marrow

Question 4

What is the location of spleen

Answer 4

Upper left portion of abdominal cavity beneath diaphragm and behind stomach enclosed in capsule of connective tissue and smooth muscle fibres

Question 5

What divides spleen in to lobes

Answer 5

The one capsule of spleen

Question 6

What is the area where blood vessels enter spleen

Answer 6

The hilum

Question 7

Explain white and red pulp

Answer 7

White pulp= forms island or nodules in the lobulesAnd containing large numbers of lymphocytes. These are responsible for white colour
Red pulp= consisting of sinuses containing large amounts blood (red colour)

Question 8

How do red blood cells enter spleen

Answer 8

They can squeeze through pores in walls of sinuses

Question 9

Does spleen contain macrophages

Answer 9

Yes about 15% of total spleen in body

Question 10

Name function of spleen

Answer 10

1. Produces red blood cells in foetal life = may regain function post-natally then called extramedullary or ectopic erythropoiesis
2. Blood reservoir - not important in man
3. Fitter for blood. Macrophages remove damaged and abnormal red blood cells, foreign particles and parasites e.g malaria
4. producer und stores lymphocytes especially t= cells

Question 11

What functions are also associated with spleen

Answer 11

The release of platelets
When hyperactive = destroy red blood cells,neutrophils and blood platelets= hyperslenism
Results in anaemia, neutropenia and thrombocytopenia

Question 12

What hormones is produced by spleen

Answer 12

Trrombopoertin= a protein like substance isolated from the spleen 15 d hormone which stimulates megakaryocyte proliferation and thus thrombocyte production

Question 13

Explain how spleen removes old cells

Answer 13

Blood cells passing through the splenic pulp better entering the sinuses undergo thorough squeezing which=
Fragile red blood cells are destroyed
After the e cells rupture, the released hemoglobin and the cell stroma are digested by the reticuloendothelial cells of the spleen
Products of digestion are mainly reused by the body as nutrients often for making new blood cells

Question 14

Reticuloendothelial cells of the spleen

Answer 14

• The pulp of the spleen contains many large phagocytic reticuluendothelial cells
• venous the blood is invaded by infectious agents,the e reticule endothelia/ cells of the spleen rapidly remove debris bacteria, parasites