Splenomegaly

Question 1

Splenomegaly causes?
(Abnormal flow/portal HTN, infiltrative, increased/abnormal splenic function)

Answer 1

▸ Hepatic cirrhosis
▸ Splenic vein thrombosis (e.g. from pancreatitis or pancreatic cancer)
▸ Schistosomiasis (in endemic areas)

Question 2

Splenomegaly causes?
(Abnormal flow, infiltrative, increased/abnormal splenic function)

Answer 2

▸ Myeloproliferative or lymphoproliferative malignancies (e.g. CML, CLL, myelofibrosis)
▸ Sarcoidosis, amyloidosis, Gaucher’s disease

Question 3

Splenomegaly causes?
[Abnormal flow, infiltrative, increased splenic activity (hypersplenism)]

Answer 3

▸ Haemolytic anaemias (hereditary spherocytosis, thalassaemia, sickle cell)
▸ Chronic infections (malaria, leishmaniasis, EBV/CMV)
▸ Autoimmune conditions (SLE, autoimmune haemolysis, Felty’s syndrome)