Spondyloarthropathies Flashcards

(37 cards)

1
Q

What are spondyloarthropathies

A

Group of related inflammatory arthropathies

  • inflamm of the spine - axial inflammation
  • sacro iliac joint involvement
  • enthesis
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2
Q

Association with spondyloarthropathy

What isn’t associated with spondyloarthropathy

A

HLA B27
No association with RhF
FHx - psoriasis, IBS, inflam spine condition

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3
Q

What is enthesopathy/enthesitis

A

Inflam of the enthesis which is the point of attachment of a ligament or tendon to bone - this is the feature that distinguishes this group from the conditions which mainly affect the synovium - RA

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4
Q

What are the principle spondyloarthropathies

A
Ank spondylitis 
Psoriasis 
Reactive arthritis 
Enteropathic spondyloarthropathy 
- IBD related arthritis 
Undifferentiated spondylarthrpathy
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5
Q

Common features of spondyloarthropathies

A

Sacroiliac and spinal involvement
Enthesis
Peripheral asymmetrical arthroscopic, oligoarthritis, mainly in the lower limb
Dactylitis - inflammation of the whole digit not just the joint
Ocular involvement- anterior uveitis
Skin lesions - psoriasis, balantis, keratoderma blenorrhagica.

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6
Q

Symptoms of sacroiliac and spinal involvement

A
Young <50 
Chronic pain
Morning stiffness >30 min 
Rest does not alleviate the pain 
Improved by movement
Night pain 
Buttock pain - radiate to the legs
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7
Q

Enthesis symptoms

A

Common sites of involvement - achilles, plantar fascia, infrapatella poles,ASIS, lateral epicondyle
Need to ask about other sites of pain - heel pain, ankle pain, tennis elbow?

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8
Q

Peripheral asymmetric arthritis

A

Not always a feature, synovitis not always present
- assymetrical
Large joint
Lower limb
Could be a monoarthritis -need to rule out, septic, crystal

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9
Q

Dactylitis what is it

A

Whole digit pain swollen - inflamm, joint, tendon, periarticular all involved
Sausage digit common is psoriatic and reactive

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10
Q

Ocular inflamm

A

Ask about painful red eye +photophobia

- recurrent

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11
Q

Skin involvement

A

Search for psoriasis
Scaly plaque - pit, onycholysis, - reactive
Keratoderma blenorrhagica
Psoriaisis - DIP

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12
Q

Ank spond epidemiology and symptoms

A

Inflamm back pain and stiffness. - worse in morn, wake up at night with pain , lasts >30 min stiffness
Young adults average age 27 years
Systemic symptoms - fatigue and weight loss
Can get peripheral synovitis = hip and shoulder
Chest wall pain - costovertebal, costchondral pain can also get reduced chest expansion because of this
Uveitis, enthesitis, aortitis, plum fibrosis - hypoventilation due to defect in the chest wall

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13
Q

How to diagnose ank spond - criteria

A
Inflamm back pain >3 months +1 more 
- buttock pain 
-sacroilitis XR
- enterosopathy 
- +ve FHx
- IBD
- urethritis, cervicitis, diarrhoea 
NEW YORK CRITERIA 
1) limited lumbar motion 
2) low back pain 3 months - improved by exercise not relieved by rest 
3) dec chest expansion
4) bilateral 2-4  grade S1 x ray 
5) unilateral 3-4 grade SI XR
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14
Q

What is the Schoenberg manoeuvre

A

Find the PSIS draw a line 10 cm above and 5 cm below
Flex the lumbar spine, knees and hips straight, if the distance inc by 5 cm or above this is normal if it doesn’t abnormal
Shows spine flexibility is impaired

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15
Q

SI grades on XR

A

0 - normal
1 - suspicious
2 -minimal change with small areas of erosion/ sclerosis with normal SI width
3-definite mod - advanced SI+erosion, sclerosis, and partial ankylosis
4- total ankylosis of SI

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16
Q

Signs of spondyloarthropathy on XR

A

Squaring of the vertebrae
Bamboo spine
- gradual interosseous bridging and joint ossification
- syndesmophytes = join 1 vertebra to the body of the next - bamboo spine
Can also get - ligament ossification

17
Q

Ix ank spond

A
Inflamm marker CRP, ESR inc 
FBC normocytic anaemia - chronic disease 
Elevated IgA
Inc ALK
HLA B27 
Plain x ray 
Isotope bone can 
MRI 
CT
US - enthesitis
18
Q

What imaging is used as early markers may not be picked up with the other imaging

19
Q

Mx ank spond

A

Con - physio,OT, hydrotherapy,, education,support groups - NASS
Med - Analgesia, NSAIDS
NO ROLE FOR DMARDS
BIOLIGICS

20
Q

What is used to asses the severity of the ank spond

A

BASDAI
Bath ank spond disease activity index
0-10 score based on the answers provided by the patient

21
Q

What is psoriatic arthritis

A

Chronic inflamm arthritis found in approx 5% of psoriasis patients
50% have spondyloarthropathy, enthesis, axial disease

22
Q

What are the patterns of psoriatic arthritis

A
  • predominant spondylitis
  • predominant DIP
  • oligoarthrits asymmetrical large joint
  • predominant plyarticular symmetrical large and small - mimic RA
  • Arthritis mutilans
23
Q

Clinical characteristics of psoriatic arthritis

A
Inflam arth DIP
Asymmetrical 
Dactylitis 
Nail - pitting, onycholysis
No rhem factor, no nodules
Erosive arthritis without osteopenia - rule out RA
Sacroilitis  - asymptomatic 
Syndesmophytes
Paravertenral assification
Enthesopathy
24
Q

Classic XR findings - psoriatic arthritis

A

Erosion, - penicil in a cup

25
Mx - psoriatic arthritis
Con - physio, OT, hydrotherapy, orthotics Med - analgesia, NSAIDS, DMARDS - ciclosporin, methotrexate Biological - anti TNF alpha Corticosteroid - oral IM intrarticular Skin psoriasis - if steroid stopped suddenly - pustular psoriasis
26
Reactive arthritis what is it
Inflam arthritis 2-4 weeks post GI, GU infection
27
How does reactive arthritis happen
Immunological phenomenon | - there is no inoculation of the joint itself - it is always sterile
28
Common GI GU infections in relative arthritis
GI - shigella, salmonella, campylobacter GU - <35 yrs - STI - chlamydia, gonorrhoea Over 35 - UTI , urethritis
29
Presentation
Lower limb arthritis Oligoarthrits = knee ankle hip Lower back and buttock pain Systemic features - unwell, temp conjunctivitis, skin - keratoderma blenorrhagica
30
Ix reactive
GI - stool culture GU - GUM clinic as may be asymptomatic Routine blood CRP, joint aspiration -esp if mono rule out septic,gout XR, MRI SIJ
31
Mx reactive
Self limiting Tx underlying Symptoms - NSAIDS, analgesia, drain or corticosteroid DMARDS - depends on severity
32
Triad reactive arthritis
Urethritis Conjunctivitis Reactive arthritis
33
What is enteropathic arthritis
Arthritis associated with IBD - UC and crohns
34
How does enteropathic arthritis present
Axial involvement SI joint peripheral arthritis lowerlimb
35
What does the peripheral arthritis in enteropathic symptoms correlate with What is it not associated with
Develops in 20% of IBD Activity of bowel disease No HLA B27
36
Spondylitis in enteropathic arthritis
Sacroilitis and spondylits develops in 10% Clinically indistinguishable from ank spon Spondylitis - no correlation with boweldisease HLA B27 present in 50% of patients
37
Tx enteropathic
DMARDS - bowel and joint- sulphasaizine antiTNF alpha