SSRI

Question 1

Axn?

Answer 1

inhibit: SERT –> increase 5-HT

Question 2

Drugs

Answer 2

1) Fluoxetine (4-6wks elim -> Norfluoextine: 7-9days)
2) Fluvoxamine (MDD)
3) (es)Citalopram
4) Sertraline

5) Paroxetine
- both these T1/2 = 25-35Hrs)

6) Dapoxetine

Question 3

Side

Answer 3

5-HT2 Stim:

• insomnia
• anxiety
• Sexual Dysfunction (premat ejac)

5-HT3 Stim:
- GI Disturb (Nausea/vomit/diahorrhea)

Hyponatremia (SIADH)

Question 4

Instruction

Answer 4

• give fraction doses
• after meal (GI problems)
• Morning (insomnia)

Question 5

Indication

Answer 5

1) 1st line anti dep
- 1/3 respond –> 6-12 months

2) Anxiety –> 2-3 wks develop, 1-2months for full effect DIAZEPAM ACUTELY
3) Bulemia Nervosa
4) Social Anxiety
5) Premenstrual Dysphoric Disorder

Question 6

COntra

Answer 6

-Pregnancy

Question 7

Toxicity

Answer 7

With MAO inhib/TCA:

SEROTONIN SYN

• > hyperthermia
• > seizures
• > coma
• > HT
• > Hyperactive Bowels

Mx:

• discont
• vital signs
• CYPROHEPTADINE (5-HT2 ATG)