SSRIs Flashcards
(28 cards)
Brand name of Citalopram
Celexa
Celexa “cits” on the pram
Brand name of Escitalopram
Lexapro
Lexa ES “cits” on the pram.. Escitalopram
Brand name(s) of Fluoxetine
Prozac/Sarafem
Oh, who had the FLU, oh? Poor Proz(ac) & stuffy Sara(fem) had the Flu.. Fluoxetine
Brand name of Fluvoxemine
Luvox
Even Fluv needs some Luv! <3
Brand name(s) of Paroxetine
Paxil, Brisdelle, Pexeva
Who is a paradox?
PaxBriPex is like a Paradox.. Paroxetine
Brand name of Sertraline
Zoloft
Sert-ainly, there are many Zoloft ads everywhere
Which are the more “activating” of SSRIs?
Fluoxetine, Paroxetine
Oh flu & the paradox are bad
Which is associated w/ baby malformations in 1st trimester?
Paroxetine
Adverse rxs of SSRIs? (3)
Adverse rxs of SSRIs? (3)
1) trigger mania in pts with BP
2) serotonin syndrome
3) syndrome of inappropriate antidiuretic hormone secretion (SIADH)
What is syndrome of inappropriate antidiuretic hormone secretion (SIADH)?
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is a condition in which the body makes too much antidiuretic hormone (ADH). This hormone helps the kidneys control the amount of water your body loses through the urine. SIADH causes the body to retain too much water
What are the SSRIs? (6)
- Paroxetine – Paxil, Brisdelle, Pexeva
- Sertraline – Zoloft
- Citalopram – Celexa
- Escitalopram – Lexapro
- Fluoxetine – Prozac/Sarafem
- Fluvoxemine – Luvox
SSRIs = CEFFSPS
P.S. listen to myCEFF!
___________ neurotransmission is the neural basis for mood, reward, pleasure, motivation, and related cognitive and executive functions
Monoaminergic
Monoaminergic neurotransmission is the neural basis for mood, reward, pleasure, motivation, and related cognitive and executive functions
Aberrant DA and NE signaling –> adversely influence ______ and related ________
motivation and EF
Aberrant DA and NE signaling –> adversely influence motivation and related executive functions
Impaired _______ neurotransmission –> anhedonia, guilt, and similar ‘negative affects’ of depression
Serotonin/5HT
Impaired serotonin/5HT neurotransmission –> anhedonia, guilt, and similar ‘negative affects’ of depression
_______ and _______ have descending spinal pathways that mediate physical fatigue and related somatic symptoms
Serotonin/5HT and NE
Serotonin/5HT and NE have descending spinal pathways that mediate physical fatigue and related somatic symptoms
Do SSRIs result in more or less serotonin being available in the synapse?
More!
It results in more serotonin being available in the synapse and thus an amplified transmission.
What happens if serotonin syndrome goes untreated?
if serotonin syndrome goes untreated:
elevated temperature and blood pressure, excessive muscle tension, muscle breakdown (rhabdomyolysis), kidney failure, coma, and death
Where is Antidiuretic Hormone (ADH) released and stored?
Antidiuretic Hormone (ADH) is released by hypothalamus and stored in the posterior pituitary
Antidiuretic Hormone (ADH) acts on what organ and does what?
ADH acts on the kidneys to retain/reabsorb more water
SIADH: syndrome of inappropriate antidiuretic hormone secretion can result in a higher blood volume, aka ________
hypervolemia
SIADH: syndrome of inappropriate antidiuretic hormone secretion can result in a higher blood volume hypervolemia
SIADH: syndrome of inappropriate antidiuretic hormone secretion can lead to a dilutional lowering of the blood’s sodium concentration, aka _________
hyponatremia
SIADH: syndrome of inappropriate antidiuretic hormone secretion can lead to a dilutional lowering of the blood’s sodium concentration, aka hyponatremia
True or False: SSRIs should not be stopped abruptly as this will result in discontinuation syndrome
True!
SSRIs should not be stopped abruptly as this will result in discontinuation syndrome
True or False: SSRIs pass into breast milk, if patient can not stop the medication breast-feeding should not be started
True
SSRIs pass into breast milk, if patient can not stop the medication breast-feeding should not be started
Babies exposed to SSRI antidepressants late in the _________ trimester of pregnancy may develop complications after birth:
respiratory distress, cyanosis (bluish skin tone from lack of oxygen), irritability, tremor, constant crying, feeding difficulty, and other symptoms.
Babies exposed to SSRI antidepressants late in the THIRD trimester of pregnancy may develop complications after birth:
respiratory distress, cyanosis (bluish skin tone from lack of oxygen), irritability, tremor, constant crying, feeding difficulty, and other symptoms.
