STD antifungals- Candidiasis (which isnt an STD...)

Question 1

The drugs that treat Candidiasis end in?

Answer 1

“conazole”

Question 2

MOA of these topical imidazoles?

Answer 2

Block ergosterol synthesis by inhibiting 14-alpha demehtylase (a fungal CYP necessary for conversion of lanosterol –> ergosterol)

Question 3

These are topical ointments. What percentage of the drug becomes systematized? What happens to systematized drug?

Answer 3

About 30%. This is extensively metabolized & eliminated almost exclusively in stool

Question 4

Which conazoles must be obtained via prescription?

Answer 4

Butoconazole (can also be OTC), Terconazole, Fluconazole

Question 5

Which conazoles can be obtained OTC?

Answer 5

Butoconazole (prescription too), Clotrimazole, Miconazole, Tioconazole

Question 6

What AE’s can the conazoles have in fetus?

Answer 6

Abdominal wall defects, Cleft palate (**recommended to avoid these drugs in first trimester)

Question 7

What other Sweatmany AE do these topical oils have?

Answer 7

They weaken latex condoms & diaphragms

Question 8

How are the topical conazoles administered? (3 different ways). And how long are they used for?

Answer 8

1. 1-2& intravaginal cream
2. Vaginal suppository
3. Vaginal tablet
   * *Taken for 3-14 nights

Question 9

How is Fluconazole different?

Answer 9

Administered orally, widely distributed in tissues & fluids, renal elim (instead of fecal)