Stem Cell Theory of Hematopoiesis

Question 1

All cells are derived from a pool of stem cells that are

Answer 1

self-renewing

Question 2

give rise to committed stem cells for each line

Answer 2

Pluripotential and multipotential stem cells

Question 3

T/F. Committed stem cells have receptors for specific growth factors

Answer 3

True

Question 4

Respond to stimulation by division and maturation (precursor cell stages) into

Answer 4

end-stage cells

Question 5

T/F. In healthy individual, only immature/immature RBCs are seen in the peripheral

Answer 5

False, only mature/mature RBCs

Question 6

Hematopoietic cells originates from common cell which is the

Answer 6

Pluripotent Stem Cell

Question 7

PSC will be divided into:
(which are also the category of leukemia)

Answer 7

Lymphoid stem cell and Myeloid stem cell

Question 8

seen on Hodgkin’s and Non-hodgkin’s

Answer 8

Lymphoid Cancer

Question 9

happens few hours after the fertilization of ovum → will be develop into any cell type → fetus

Answer 9

Totipotent

Question 10

develops after several days → will be develop into any cell type but not a fetus

Answer 10

Pluripotent

Question 11

will be found in the BM, Neural SC, Muscle SC, Liver SC

Answer 11

Multipotent

Question 12

major regulator of erythropoiesis, stimulates erythroid CFU cells and proerythroblasts

Answer 12

Erythropoietin (EPO)

Question 13

increases platelet production, stimulates megakaryocytes CFU cells

Answer 13

Thrombopoietin (TPO)

Question 14

increases production of neutrophils, stimulate granulocyte-macrophage CFU cells

Answer 14

Granulocyte CSF (G-CSF)

Question 15

increases macrophage production, stimulates granulocyte-macrophage CFU cells

Answer 15

Granulocyte-Macrophage CSF (GM-CSF)

Question 16

stimulate B-and T-cell formation, function together with G-CSF and GM-CSF; produces by wide variety of cells and most of them are glycoproteins

Answer 16

Interleukins

Question 17

CFU

Answer 17

Colony Forming Unit

Question 18

CSF

Answer 18

Colony Stimulation Factor

Question 19

molecules secreted to give signals to other cells

Answer 19

Cytokines (G-CSF, GM-CSF, Interleukins)

Question 20

pro-protein

Answer 20

Precursors

Question 21

The circulatory system is made up of blood vessels and endothelium. These are the pathways where blood goes

Answer 21

Blood Vessels

Question 22

carries high oxygen content from the lungs → send away from the heart to the body

Answer 22

Arteries

Question 23

4 iron = __ oxygen

Answer 23

4

Question 24

low O2 from the body to the heart → to reoxygenate in the lungs

Answer 24

Veins

Question 25

small blood vessels that connects arteries to capillaries

Answer 25

Arterioles

Question 26

small blood vessels that connects capillaries and veins

Answer 26

Venules

Question 27

tiny blood vessels that contains blood components and connects arterioles and venules

Answer 27

Capillaries

Question 28

Thin layer of cells that lines the interior surface of blood vessels and forms the physical and biological barrier.

Answer 28

Endothelium

Question 29

Responsible for primary and secondary hemostasis to stop or prevent hemolysis

Answer 29

Endothelium

Question 30

innermost layer, made up of squamous endothelium

Answer 30

Tunica Intima

Question 31

middle layer, made up of smooth muscle and elastic fibers

Answer 31

Tunica Media

Question 32

outermost layer, made up of connective tissues

Answer 32

Tunica Externa or Adventitia