Steotic Liver Disease

Question 1

Fat accumulation in the form of TGs within the liver

Answer 1

MASLD

Question 2

A fat accumulation of >___% of the weight of the liver is needed for diagnosis

Answer 2

5

Question 3

What are 2 risk factors for MASLD?

Answer 3

1. Obesity
2. Insulin resistance

Question 4

The progression of MASH generally occurs when?

Answer 4

Over time if lifestyle modification is ineffective

Question 5

MASH and MASLD combined are now the ____ cause of liver disease

Answer 5

1

Question 6

What drug class is used to manage MASLD/MASH?

Answer 6

Statins

Question 7

What 2 drugs are used to treat MASLD/MASH?

Answer 7

1. Atorvastatin
2. Pravastatin

Question 8

What lifestyle modification can be utilized to manage MASLD/MASH?

Answer 8

Weight loss of 10%

Question 9

What are the 2 types of drug induced liver disease?

Answer 9

1. Intrinsic
2. Idiopathic

Question 10

What type of drug induced liver disease is dose dependent?

Answer 10

Intrinsic

Question 11

What type of drug induced liver disease is usually caused by an allergic reaction?

Answer 11

Idiopathic

Question 12

What 3 physical findings are used for a diagnosis of exclusion?

Answer 12

1. Rash
2. Fever
3. Signs of chronic liver disease

Question 13

What is the most common cause of drug induced liver injury?

Answer 13

Acetaminophen

Question 14

What does acetaminophen have a direct toxic effect on?

Answer 14

Hepatocytes

Question 15

What metabolite is the hepatotoxic metabolite?

Answer 15

NAPQI

Question 16

What is the antidote for a Tylenol overdose?

Answer 16

N-acetylcysteine

Question 17

What 4 drugs are considered Idiopathic?

Answer 17

1. Augmentin
2. NSAIDs
3. Phenytoin
4. Nitrofurantoin

Question 18

What 4 drugs are considered intrinsic?

Answer 18

1. Isoniazid
2. Valproate
3. Azothioprine
4. Amiodarone

Question 19

What organ does amiodarone not effect?

Answer 19

Kidneys

Question 20

What drug class is 2nd to Tylenol in drug related hepatotoxicity?

Answer 20

Herbals and dietary supplements

Question 21

What are anabolic steroids associated with?

Answer 21

Prolonged jaundice

Question 22

Inherited disorder due to high rates of blood transfusions

Answer 22

Hemochromatosis

Question 23

When is hemochromatosis asymptomatic until?

Answer 23

90% of the liver has iron deposition

Question 24

What 2 ways can you manage hemochromatosis?

Answer 24

1. Weekly phlebotomy
2. In sickle cell disease: iron chelation therapy

Question 25

What metal accumulates with Wilson’s disease?

Answer 25

Copper

Question 26

What is a sign of Wilson’s disease?

Answer 26

Kayser-Fleischer rings

Question 27

How would you treat Wilson’s disease?

Answer 27

1. Copper chelation therapy 2. Penicillamine or trientine

Question 28

Fulminant liver failure has an acute onset of _______ and impaired ________?

Answer 28

Encephalopathy; synthetic function

Question 29

What is the most common precipitating factor of fulminant liver failure?

Answer 29

APAP Toxicity

Question 30

What is fulminant liver failure not usually caused by?

Answer 30

Alcohol

Question 31

How would you treat fulminant liver failure?

Answer 31

Remove the offending cause

Question 32

What is listing on the transplant list dependent on?

Answer 32

MELD score

Question 33

What are 2 contraindications for a liver transplant?

Answer 33

1. Life threatening systemic disease 2. Active drug and alcohol abuse

Question 34

What are 4 relative contraindications for a liver transplant?

Answer 34

1. HIV 2. >70 3. Portal vein thrombosis 4. Severe hypoxia

Question 35

If you get a liver from a living donor, what part of the liver is donated?

Answer 35

Left lobe