Step Studies

Question 1

Step 1 Weight Loss 68

Answer 1

-14.9 / -2.4

Question 2

Step 1 Waist Circumference

Answer 2

5.3 / 1.6

Question 3

Step 1 % >5

Answer 3

83.5% / 31.3

Question 4

Step 1 Design

Answer 4

2:1 randomization 68 Week randomized, double blinded, placebo controlled

Question 5

Step 1 AE Discontinue

Answer 5

7.0%/ 3.1%

Question 6

Step 4 Study Run In

Answer 6

20 Week
16 week to get to 2.4 dose

Question 7

Step 4 20-68 week outcome

Answer 7

Wegovy -7.9/ +6.9

Question 8

Step 4 Secondary from week 0

Answer 8

Wegovy -17.4/ -5.0

Question 9

Step 4 Objective

Answer 9

Effectively & Safety Wegovy for chronic weight management specifically in pts able to reach target 2.4 dose at 20 weeks

Question 10

Step 4 trial set up

Answer 10

2;1 randomization 908 pts randomized double blinded placebo controlled withdrawal trial

Question 11

Step 4 Discontinued during run in

Answer 11

5.3% patients GI related issues

Question 12

Eating for pleasure -food reward

Answer 12

Hedonic

Question 13

Eating for Hunger -meeting energy requirements

Answer 13

Homeostasis

Question 14

Deciding to Eat

Answer 14

Executive function

Question 15

Reduction in leptin after weight loss

Answer 15

Increase in appetite

Question 16

Step 5 Study

Answer 16

Long term weight management 1;1 randomized 104 week

Question 17

Step 5 Weight reduction end of study

Answer 17

-15.2% / -2.6%

Question 18

Step 5 % of patients to get >5 %

Answer 18

77.1% /34.4%

Question 19

Step 5 AE discontinue

Answer 19

6% Wegovy/ 15% Placebo

Question 20

Step 5 Waist Circumference

Answer 20

Wegovy 5.7/ 2.0

Question 21

Half Life of Wegovy

Answer 21

7 Days

Question 22

% of endogenous hormone

Answer 22

94%

Question 23

What is the Hunger Hormone- produces

Answer 23

Ghrelin - stomach

Question 24

When are blood levels of Ghrelin highest

Answer 24

Before meals

Question 25

Type of Study Select?

Answer 25

CVOT Event Driven Superiority

Question 26

How was Select Randomized

Answer 26

1:1 Wegovy/ placebo & standard of care

Question 27

% of MACE reduction

Answer 27

20% superior to placebo

Question 28

Duration of study

Answer 28

41.8 months

Question 29

Patients with 1st MACE in Select

Answer 29

6.5%/ 8.0

Question 30

Step 4 Waist Circumference

Answer 30

2.5 Wegovy/ 1.3

Question 31

Second Endpoint of MASE Weight Select

Answer 31

9.4% Wegovy/0.9 %

Question 32

Contrave made of?

Answer 32

Generic name: bupropion and naltrexone

Question 33

contains a combination of phentermine and topiramate

Answer 33

Qysimia

Question 34

.25 .5 1 Wegovy

Answer 34

.5 ML pens

Question 35

1.7 /2.4

Answer 35

.75ml

Question 36

Temperature

Answer 36

46-86 Good for 28 days out prescription 28 days