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Pathophys 2, Midterm > STI's > Flashcards

STI's Flashcards

1
Q

What are the bacterial STI’s ?

A

Chlamydia
Gonorrhea
Syphilis

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2
Q

What are the viral STI’s ?

A

HPV
Hepatitis B
HSV
HIV

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3
Q

What are the parasitic infections?

A

Lice

Mites (scabies)

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4
Q

What is the gonorrhea transmission?

A

Intercourse and congenital

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5
Q

What is a folite?

A

Contaminated objects

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6
Q

What does gonorrhea need to survive?

A

Co2 and nutrients

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7
Q

What is the pathophys of gonorrhea?

A

Female: infected cervix -> uterus + fallopian tubes
Male: urethra rectum (stays there)

Attached to epithelium -> mucosal invasion + damage

Intense inflammation -> urethra/uterus fills with exudate

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8
Q

What are the manifestations of gonorrhea ?

A

Ophtamlmia neonatorum
Pharyngitis
Rectal bleed and discharge
Conjunctivitis

Female: pelvic inflammation disease (PID) & fallopian tube inflammation
Increase infertility risk

Male: urethral strictures: prostatis, epididymitis

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9
Q

What are the stages of syphilis?

A
  1. Local invasion
  2. Systemic. Immune response. Condolymata lata.
  3. latent
  4. Morbidity, Gummas, hypersensitivity ulcers, heart/skin/bone/neuro
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10
Q

What is the mode of transmission of syphilis ?

A

Extragenital
Intercourse
Congenital

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11
Q

What is the specification of Chlamydia?

A

Behaves like a virus

Elementary body =resilient inactive bacteria
➡️ entry via attachment and endocytosis ➡️ elementary body ➡️ reticulate body = active replication bacteria

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12
Q

What is the transmission mode of chlamydia?

A

Intercourse

Congenital

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13
Q

What are the manifestations of chlamydia ?

A

Frequently asymptomatic

Ocular trachoma
Lymphogranuloma strain

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14
Q

What are the transmission mode of genital herpes?

A

Intercourse
Congenital

Women more than men

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15
Q

What is the pathophys of genital herpes?

A

Skin opening ➡️ replication ➡️ neurons ➡️ sacfal nerve ➡️ latency in dorsal root ganglion ➡️ stress/immunosup/metruation/UVB ➡️ reactivation

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16
Q

What are the manifestations of genital herpes ?

A
  1. Non-primary HSV (with hsv antibodies) ➡️ less sx and shedding lesions
  2. Primary genital infection (no Ab) ➡️ fever, muscles ache, less diuresis
  3. Recurrent infections (HSV 2 more than 1) ➡️ mild local Sx, shedding lesions
  4. Neonate infection (CNS lesions, seizures, mortality)
17
Q

What are the mkst danferous strands of human papillomavirus ?

A

6, 11, 16, 18

18
Q

What are the HPV (papillomavirus) manif?

A

Condylomara acuminate

  • contagious ++
  • painful Intercourse
  • bleed easy

Giat cauliflower-like condylomata acuminate (cancer?)

19
Q

What is scabies ?

A

Mites burrow to lay eggs
Long skin expo to parasites (intercourse, fomites)

Manif: pruritus

20
Q

What is HIV?

A

RNA retrovirus

21
Q

What cells does HIV target?

A

CD4 helper t-cells & macrophages

22
Q

Wjat is thhe HIV life cycle?

A
  1. Virion bind to CD4 + chemokin receptor
  2. Fusion whit HIV membrane and host membrane
  3. Entry of viral genome in cytoplasm
  4. HIV RNA + reverse transcriptase = proviral DNA
  5. Intregration of provirus (DNA integrase) in host cell genome
  6. Synthesis HIV proteins
  7. Assemble virions
  8. Exocytosis
  9. Release of mature virion (new HIV virion)
23
Q

What are the crucial HIV proteins?

A

gp120: CD4 $ CXCR4 or CCR5 binding
gp41: entry across membrane

Reverse transcriptase: RNA -> DNA conversion
DNA integrase: DNA insertion in host genome

24
Q

How does HIV becomme AIDS?

A

Increase in HIV count

Decrease in CD4 + Th count

25
Q

Ehat are the infection sites of HIV?

A
  1. Lymph nodes
  2. Dendritic cell and mucosal T-cells spread infection
  3. Sometime Thymus and bone marrow involved
  4. Reservoirs (GI, CNS)
26
Q

What are the manifestations of HIV?

A 
Kaposi sarcoma
Anorexia
HSV
Cytom egalovirus
Retinitis
Vision deficits
27
Q

What is a window period, in HIV?

A

Virus present, but no antibodies

28
Q

What happens to HIV infected cells?

A

Killed by cytotoxic T-cels

29
Q

What happens to unifected cells?

A

Inderect induction of apoptosis

By gp120 and partial fusion

30
Q

HIV to AIDS progression

A 
Seropositive test (antibodies p4)
Clinical latency

CD4 count less than 200 cells/ul

Pathophys 2, Midterm (4 decks)

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