STIs Flashcards
(33 cards)
3 basic microbial testing for STIs
1. NAATs nucleic acid amplification testing rely on detection of DNA used for chlamydia and n.gonnorhoea PCR can also be used for herpes
- microscopy, culture and sensitivity
for gonorrhoea, candida, bacterial vaginosis, trichomonas vaginalis - blood tests
syphilis, HIV, hepatitis
chlamydia symptoms
Female
post-coital bleeding, abdo tender, pelvic tender, infertility, Reiter’s syndrome, proctitis, pharyngitis, perihepatitis
which serotypes of chlamydia give lymphogrnauloma venereum cancer
L1, L2, L3
complications of chlamydia
PID (1-30%)
sexually acquired arthritis (urethritis, arthritis, conjunctivitis = reiter’s)
epididymo-orchitis
peri-hepatitis
manifestations of neonatal chlamydia
conjunctivitis 5-12 days after births
pneumonia 1-3 months
chlamydia treatment
doxycycline 100mg for 7/7
avoid sexual contact for duration of treatment
partner notification
how does lymphogranuloma venerum present
solitary genital lesion
proctitis
lymphadenopathy
TREAT doxycycline
neonatal gonorrhea
opthalmia neonatorum - blindness :(
treatment for gonorrhoea
ceftriaxone 1g IM !!!!
ciprofloxacin 500mg orally
then test of cure NAAT if asymptomatic
when do you have to notify partner if gonorrhoea?
symptomatic male:
asymptomatic/other sites
all partners within preceding 2 weeks (or last partner if over 2 weeks ago)
asymptomatic/other sites: preceding 3 months
what’s the most common cause of abnormal vaginal discharge in women of child bearing age?
bacterial vaginosis
overgrowth of lactobacilli
offensive fishy odour withour itch/irritation
treating bacterial vaginosis
metronidazole
presentation of thrush
itch
vulval pain
superficial dyspareunia
curd like white vaginal discharge
treatment of thrush
topical clotrimazole
primary syphilis
hard genital or oral ulcer called a CHANCRE at site of infection for 3 weeks
secondary syphilis
red maculopapular rash anywhere plus pale moist papules in urogenital region and mouth (lies latent for 3-30 years)
tertiary syphilis
degeneration of Ns
aneurysms
granulomatous lesions in liver, skin, bones (gummas) in 40% patients
when does congenital syphilis get passed to child?
placental transfer after 10-15 weeks
can cause death or spontaneous abortion of foetus
survivors -> secondary syphilis symptoms
what does HPV cause
hyperplastic epithelial lesions
important HPV types
6, 11 = genital warts
16, 18 = cancer
treatment for 6,11 HPV genital warts
podophyllum (cream)
cryo
laser
surgery
HPV vaccine based on what?
Two types
VLP1 a major capsid protein
Cervarix (bivalent)
Gardasil (quadrivalent)
Herpes Simplex Virus Type 1
affects oral region and causes cold sores
Herpes Simplex Virus Type 2
genital infection (penis, anus, vagina)
