STIs (Exam #3)

Question 1

What organism involves fibronectin coat?

Answer 1

Treponema pallidum = Syphilis

- STI

Question 2

What are three characteristics of a Chancre, and what organism is it associated with?

Answer 2

Treponema pallidum = Syphilis (STI)

• Firm
• Raised edges
• Indurated

Question 3

What signs/sxs are seen with Primary Syphilis?

Answer 3

Chancre

Question 4

What signs/sxs are seen with Secondary Syphilis (2)?

Answer 4

• Maculopapular rash

- Condyloma lata

Question 5

What signs/sxs are seen with Tertiary Syphilis (3)?

Answer 5

• Neurosyphilis
• Cardiovascular syphilis
• Granulomata (gummas)

Question 6

What stage of latency in Syphilis is more associated with relapse/progression to Tertiary Syphilis?

Answer 6

EARLY latency (within 1 year of infection)

Question 7

What are the three primary diagnostic tools used for Syphilis?

Answer 7

• CLINICAL = chancre
• Nontreponemal tests = VDRL, RPR
• Treponemal tests (specific) = FTA-ABS

Question 8

What three symptoms are associated with Congenital Syphilis?

Answer 8

• Maculopapular rash
• Infectious nasal discharge
• Nasal bone osteitis

Question 9

What are the three components of Hutchinson’s triad, and what organism is it associated with?

Answer 9

Treponema pallidum = Syphilis (STI)

• Notched incisors
• Interstitial keratitis
• Deafness (8th nerve)

Question 10

What organisms involves the triad of notched incisors, interstitial keratitis, deafness (8th nerve), and what is this triad called?

Answer 10

Hutchinson’s triad

- Treponema pallidum = Syphilis (STI)

Question 11

Is Treponema pallidum = Syphilis G- or G+?

Answer 11

G-

Question 12

Is Neisseria gonorrheae = Gonorrhea G- or G+?

Answer 12

G-

Question 13

Which STI organism needs lysed RBCs to grow?

Answer 13

Neisseria gonorrheae = Gonorrhea

Question 14

What organism involves antigenic variation of pili, LOS and peptidoglycan?

Answer 14

Neisseria gonorrheae = Gonorrhea

- STI

Question 15

What STI organism involves micro purulent discharge?

Answer 15

Neisseria gonorrheae = Gonorrhea

Question 16

What STI organism involves complications of acute salpingitis/PID and DGI (fever, rash, purulent arthritis)?

Answer 16

Neisseria gonorrheae = Gonorrhea

Question 17

Which STI organism needs host ATP to grow?

Answer 17

Chlamydia trachomatis = Chlamydia

Question 18

What organism involves complication of lymphogranuloma venereum?

Answer 18

Chlamydia trachomatis = Chlamydia

- STI

Question 19

What is the gold standard diagnostic test for Neisseria gonorrheae = Gonorrhea?

Answer 19

NAAT

Question 20

What is the gold standard diagnostic test for Chlamydia trachomatis = Chlamydia? What is an alternative tool?

Answer 20

Cell culture isolation

- Can also use NAAT

Question 21

What organism involves inclusion conjunctivitis in newborns?

Answer 21

Chlamydia trachomatis = Chlamydia

- STI

Question 22

Which three STIs are ulcerative?

Answer 22

• Syphilis
• Chancroid
• Genital Herpes

Question 23

Which three STIs are non-ulcerative?

Answer 23

• Gonorrhea
• Trichomoniasis
• Chlamydia

Question 24

Is Chlamydia trachomatis = Chlamydia G- or G+?

Answer 24

G-

Question 25

What STI organism is an anaerobe that presents with yellow-grey discharge?

Answer 25

Trichomonas vaginalis = Vaginitis

Question 26

What organism involves clear discharge in males; frothy, malodorous discharge in females?

Answer 26

Trichomonas vaginalis = Vaginitis | - STI

Question 27

What condition presents with pH change and is NOT an STI?

Answer 27

Bacterial Vaginosis

Question 28

How can you differentiate Trichomonas vaginalis = Vaginitis from Bacterial Vaginosis (2)?

Answer 28

- pH 4.5+ | - Presence of clue cells

Question 29

What condition presents with clue cells?

Answer 29

Bacterial Vaginosis

Question 30

What organism involves thick, white, frothy discharge with NO odor?

Answer 30

Candida albicans = Vulvovaginal Candidiasis

Question 31

What organism presents similarly to Syphilis, but involves a Chancroid?

Answer 31

Haemophilus ducreyi = Chancroid

Question 32

What organism involves a soft chancre (Chancroid)?

Answer 32

Haemophilus ducreyi = Chancroid

Question 33

What are three characteristics of a Chancroid, and what organism is it associated with?

Answer 33

- Soft (NOT raised) - Ragged edges - Sharp margins

Question 34

What is the diagnosis for Haemophilus ducreyi = Chancroid?

Answer 34

PCR

Question 35

How can you differentiate a Chancre (Treponema pallidum = Syphilis) from Chancroid (Haemophilus ducreyi) (4)?

Answer 35

- Chancre = Syphilis: HARD, RAISED edges; LOCAL and DEEPER | - Chancroid = H. ducreyi: SOFT, RAGGED edges; SPREADS easily and EXPANDS

Question 36

What are the two possible organisms that use Pelvic Inflammatory Disease (PID)?

Answer 36

- N. gonorrheae | - C. trachomatis

Question 37

What is the primary symptom associated with Pelvic Inflammatory Disease (PID)?

Answer 37

Lower abdominal pain