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ACLAM Exam 2023 > Strains and Stocks > Flashcards

Strains and Stocks Flashcards

1
Q

A

A

Albino
Age-related hearing loss
Research use: carcinogen-induced lung tumors, developmental biology (cleft palate), muscular dystrophy (dysf gene)
Spontaneous disease: high incidence of lung adenoma, predisposed to congenital malformations, amyloidosis
Hepatic tumors with H. hepaticus infection

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2
Q

AKR

A

Albino
Ecotropic retrovirus in all tissues, viremic from birth, high rate of T-cell lymphoma/leukemia
Paralysis with LDV
Males get urinary obstruction

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3
Q

129

A

16 substrains - white belly agouti (Aw) or albino.
Used for ES cell lines and to generated Tm strains
High incidence of testicular teratoma, arteritis, acidophilic macrophage pneumonia

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4
Q

BALB/c

A

Albino
Age-related hearing loss
Research use: monoclonal antibody production, plasmacytoma with injection of mineral oil
Spontaneous disease: cardiac calcinosis, hypocallosity, Reye’s-like syndrome, polycystic kidney disease

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5
Q

C3H

A

Agouti
Retinal degeneration
Spontaneous disease: cardiac calcinosis, liver tumors (hepatoma), mammary adenocarcinoma, alopecia areata
TLR4 - highly susceptible to gram negative infection

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6
Q

C57BL/6

A

Black
Hearing loss
Spontaneous disease: hydrocephaply, malocclusion, lymphoma, micropthalmia, amyloidosis, barbering/UD, postpartum ileus
Susceptible to diet-induced atherosclerosis/obesity/type 2 DM

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7
Q

DBA/2

A

Dilute brown nonagouti
Hearing loss
Spontaneous disease: cardiac + soft tissue mineralization, glaucoma, audiogenic seizures (young age)
Complement C5 deficient
Resistant to diet-induced atherosclerosis

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8
Q

FVB

A

Albino
Retinal degeneration
Research use: transgenic development due to large pronucleus, airway responsiveness/asthma, chemical-induced SCC
Spontaneous disease: epilepsy, auditory seizures

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9
Q

SJL

A

Albino
Retinal degeneration
Research use: EAE, muscular dystrophy (dysf gene)
Spontaneous disease: reticulum cell sarcoma, amyloidosis

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10
Q

SWR

A

Albino
Retinal degeneration
Research use: EAE
Spontaneous disease: lung tumors, mammary gland tumors, diabetes insipidus

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11
Q

Inbred mouse strains with retinal degeneration

A

SWR
SJL
FVB
C3H
CBA

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12
Q

Inbred mouse strains with age-related hearing loss

A

BALB/c
A
C57
129
NOD
DBA

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13
Q

Inbred mouse strains with dystrophic mineralization

A

BALB/c (epicardial)
C3H (cardiac)
DBA (cardiac + soft tissue)

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14
Q

Inbred mouse strains with audiogenic seizures

A

DBA/2 (at young ages, then hearing loss)
FVB
SJL

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15
Q

Inbred strains susceptible to primary amyloidosis

A

A
SJL
C57BL/6 (older)

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16
Q

Inbred strains resistant to primary amyloidosis

A

BALB/c
C3H

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17
Q

Inbred strains with dysf mutation

A

A
SJL

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18
Q

Inbred strains with high rates of male aggression

A

BALB/c
SJL
FVB

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19
Q

Nude mouse

A

Foxn1 gene
T cell deficient
Hairless

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20
Q

SCID mouse

A

Prkdc^scid mutation
T and B cell deficient
Susceptible to ionizing radiation

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21
Q

Rag1/Rag2 mouse

A

RAG1 or RAG2 gene
T and B cell deficient
“non-leaky”

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22
Q

NOD

A

Albino
Hearing loss
Type 1 DM
Defects in antigen presentation, T lymphocyte repertoire, NK cell function, macrophage cytokine production, and C5 complement

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23
Q

NSG

A

T and B cell deficient
NK cell deficient
Complement deficient
Impaired macrophage and dendritic cell function

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24
Q

XID

A

Burton’s tyrosine kinase gene defect
Decreased B cells, low IgM
Model of x-linked agammaglobulinemia

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25
Q

Moth-eaten

A

T and NK cell deficient
Autoimmune syndrome, hypergammaglobulinemia
Folliculitis leads to moth eaten coat

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26
Q

Beige

A

Lyst(bg) mutation
Model for Chediak-Higashi syndrome, lysosomal storage disease
Decreased NK activity, decreased neutrophil function

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27
Q

RFM mice

A

Atrial thrombosis

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28
Q

CBA

A

Research use: granulomatous experimental autoimmune thyroiditis,
Spontaneous disease: Exocrine pancreatic insufficiency, renal tubulointerstitial lesions

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29
Q

NZB

A

Autoimmune disease - hemolytic anemia, glomerulonephritis

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30
Q

Inbred strains with high rate of mammary tumors

A

C3H
A
DBA/2

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31
Q

Inbred strains with low rate of mammary tumors

A

BALB/c
C57BL
AKR

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32
Q

ACI rat

A

Black agouti with white belly and feet
Congenital genitourinary abnormalities (renal agenesis/hypoplasia, hydronephrosis)
Testicular and prostatic tumors
Susceptible to estrogen-induced mammary tumors

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33
Q

BB/Wor rat

A

Albino
Type 1 diabetes mellitus

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34
Q

BN (Brown Norway)

A

Brown
Airway hyperresponsiveness/asthma, eosinophilic granulomatous pulmonary inflammation
Bladder tumors, hydronephrosis, transplantable myeloid leukemia

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35
Q

BUF (Buffalo)

A

Albino
Autoimmune thyroiditis

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36
Q

COP (Copenhagen)

A

Hooded
Prostatic adenocarcinoma

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37
Q

F344

A

Albino
National Toxicology Program’s Carcinogen Bioassay Program and National Institute on Aging rat
Interstitial/leydig cell tumors, large granular lymphocytic leukemia, CPN, corneal mineralization, nephrocalcinosis

38
Q

LEW (Lewis)

A

Albino
Autoimmune disease model, EAE, multiple sclerosis

39
Q

LOU/C

A

Albino
Myeloma, Plasmacytoma, IgG autoantibody

40
Q

SHR

A

Albino
Spontaneous hypertensive rat
Hypertension, polyarteritis nodosa

41
Q

WF (Wistar-Furth)

A

Albino
Mononuclear cell leukemia
Fuzzy mutation - dermatology research
Inducible carcinoma of the mammary gland

42
Q

Zucker

A

Hooded
Obesity, type 2 DM
Increased incidence of urinary tract infections and urolithiasis

43
Q

Brattleboro

A

Hooded (?)
Diabetes insipidus (autosomal recessive)
Vasopressin deficiency

44
Q

Gunn

A

Albino (?)
Jaundice, unconjugated hyperbilirubinemia (autosomal recessive defect of bilirubin glucuronidation, UGT); Crigler-Najjar syndrome
Hydronephrosis (single dominant gene)

45
Q

Obese SHR

A

Type 4 hyperlipoproteinemia (autosomal recessive)

46
Q

Nude rat

A

Hooded
Foxn1 - rnu
Autosomal recessive

47
Q

Sprague Dawley

A

Outbred stock; albino
Spontaneous disease: polyarteritis nodosa, pituitary adenoma (chromophobe adenoma most common), mammary fibroadenoma, CPN, chronic myocardial disease
Larger than Wistar

48
Q

Wistar

A

Outbred stock; Albino
Seizures
Smaller than Sprague-Dawley

49
Q

Long Evans

A

Outbred stock; hooded

50
Q

Royal college of surgeons rat (RCS)

A

Tan hooded
Retinal degeneration

51
Q

Long-evans Cinnamon rat

A

“Cinnamon-like”, kinda looks tan hooded but with more tan
Copper accumulation in liver; Wilson’s disease

52
Q

Dahl rat

A

Albino
Hypertension and renal failure on high-salt diet; hyperlipidemia, insulin resistance

53
Q

FHR (Fawn-Hooded Rat)

A

Fawn hooded
Hypertension

54
Q

Substrain designation occurs if two colonies of inbred mice are…

A

Separated before F40
Separate for 100 generations
If genetic differences arise

55
Q

Wistar-Kyoto

A

Normotensive control for SHR
High rates of cardiac septal defects, resulting in right ventricular hypertrophy

56
Q

KHC Rabbit

A

Kurosawa and Kusanagi Hypercholesterolemic rabbit
Autosomal recessive - LDL receptor gene has a 12bp deletion
Elevated serum cholesterol, triglyceride, phospholipid; decreased HDL

57
Q

WHHL rabbit

A

Watanabe heritable hyperlipidemia
Marked deficiency of LDL receptors
Increased incidence of athersclerosis

58
Q

St Thomas Hospital strain rabbits

A

Normal functioning LDL receptor
Hypercholesterolemic

59
Q

IAF guinea pig

A

Hairless
Derm tox

60
Q

Abyssinian guinea pig

A

Long hair in whorls

61
Q

Peruvian guinea pig

A

Long straight hair

62
Q

Yucatan minipig

A

Grey-ish/black color
Mini and micro sizes
Lineage with VSD
Lineage that is white/hairless for derm studies

63
Q

Hanford minipig

A

Largest minipig
White
Device implant studies, dermal studies

64
Q

Sinclair minipig

A

White (lots of hair)
Malignant, spontaneously regressing, melanoma
Slow growers

65
Q

Gottingen

A

Smallest minipig
White color
Used in pharma/tox
Prone to type III hypersensitivity - thrombocytopenic purpura

66
Q

Ossabaw swine

A

Black or black/tan spotted
Diabetes and metabolic syndrome

67
Q

Rapacz familial hypercholesterolemia pigs

A

Atherosclerosis

68
Q

Norwegian yorkshire swine

A

Inherited form of autoimmune glomerulonephritis

69
Q

Gal-KO pig

A

Knockout of the gene that encodes for alpha1,3Gal
Background breed - MGH, SLAdd line (most inbred)

70
Q

MGH swine

A

Massachusetts general hospital
Homozygous for defined SLA/MHC
SLAaa, SLAcc, SLAdd
SLAdd further inbred

71
Q

Swine breeds susceptible to porcine stress syndrome

A

Landrace
Yorkshire
Duroc
Pietrain
Poland China

72
Q

Landrace pig

A

Big and white
Ears point down, long snout

73
Q

Yorkshire pig

A

Big and white
Ears point up, shorter snout

74
Q

Duroc pig

A

Big and brown

75
Q

Pietrain pig

A

White with black spots

76
Q

1.50 syrian hamster

A

Cardiomyopathy
Defect in the sarcoglycan gene

77
Q

APA hamster

A

“Albino-panda-albino” hamster
Diabetric nephropathy after STZ administration
Develop atrial thrombosis more commonly (maybe due to cardiac hypertrophy)

78
Q

Gray collies

A

Cyclic hematopoiesis
Periodic fluctuations in neutrophil population

79
Q

Golden retrievers

A

Duchenne muscular dystrophy
X-linked recessive

80
Q

Doberman pinscher

A

Narcolepsy

81
Q

Bedlington terrier

A

Copper storage (Wilson’s) disease

82
Q

Abyssinian cat

A

Retinal degeneration
rdAc

83
Q

Corriedale sheep

A

Dubin-Johnson syndrome (congenital hyperbilirubinemia)
Conjugated
Hepatic anion excretory defect
Big white and very puffy

84
Q

Southdown sheep

A

Gilbert’s syndrome (congenital hyperbilirubinemia)
Unconjugated
Hepatic anion uptake defect
Little white and only a little puffy

85
Q

Rambouillet sheep

A

Gamma-glutamyl carboxylase deficiency
Yellow-white with big horns

86
Q

Holstein cattle

A

Inherited cardiomyopathy
Leukocyte adhesion deficiency
Chediak-Higashi

87
Q

Fainting goats

A

Myotonia congenita

88
Q

Quiver quail

A

Neurofilament deficient mutant quail
Wide-spread tremors

89
Q

Complement 4 deficient guinea pig

A

Partially dominant mode of inheritence (Heterozyogtes are intermediate)
Susceptible to syphylis

90
Q

Wz guinea pig

A

Waltzing
Spontaneous
Autosomal dominant, full penetrance

ACLAM Exam 2023 (5 decks)

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