Stroke Flashcards

(46 cards)

1
Q

Define subarachnoid haemorrhage

A

Bleeding into the subarachnoid space

- between the arachnoid mater and pia mater

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2
Q

Epidemiology of subarachnoid haemorrhage

A

6-8 cases per 100,000
Average onset 50-55
Higher incidence in men and black people

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3
Q

Risk factors for subarachnoid haemorrhage

A

Hypertension
Smoking
FHx
Autosomal dominant polycystic kidney disease

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4
Q

Pathophysiology of subarachnoid haemorrhage

A

Most commonly spontaneous rupture of berry aneurysms - commonly in the anterior circle of Willis
AV malformation
Arterial dissections
Use of anticoagulants

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5
Q

Presentation of subarachnoid haemorrhage

A
Sudden onset, thunderclap headache
Photophobia
Loss of consciousness
CN III palsy - posterior communicating artery aneurysm compressing the ipsilateral CN III
N+V
Meningism
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6
Q

Ix for subarachnoid haemorrhage

A

CT head - hyperdense areas in basal cisterns, major fissures and sulci
FBC - leucocytosis
Clotting profile - may show coagulopathy - elevated INR, prolonged PTT
Troponin I - elevated in 1/4 of cases
LP - presence of RBCs or xanthochromia in 3 consecutive samples

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7
Q

Mx of subarachnoid haemorrhage

A

Cardiopulmonary support
- intubation, mechanical ventilation and sedation with benzodiazepines
- labetalol to keep systolic BP < 160
Surgical clipping/coil embolisation
Calcium channel blockers - vasospasm prophylaxis

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8
Q

Define extradural haemorrhage

A

Collection of blood between inner surface of skull and periosteal dura mater
Usually secondary to traum / skull fracture

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9
Q

Presentation of extradural haemorrhage

A

Loss of consciousness normally followed by transient recovery with ongoing headache
- caused by striping of dura from bone by expanding haemorrhage
Rapidly decreasing consciousness - haematoma enlarges increasing ICP
CN palsies - brain structures herniate

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10
Q

Ix for extradural haemorrhage

A

CT scan - bleeding limited by suture lines of skull

  • hyperdense lemon shape
  • midline shift away from bleed
  • compression of ventricles
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11
Q

Mx of extradural haemorrhage

A

Prognosis good with early intervention
A-E assessment and neuro exam
Small - observe and manage conservatively
Large - urgent referral to neurosurgery for craniotomy and clot evacuation

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12
Q

Complications of extradural haemorrhage

A
Permanent brain damage
Coma
Seizures
Weakness
Pseudoaneurysm
Arteriovenous fistula formation
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13
Q

Define subdural haematoma

A

Collection of blood between meningeal dura mater and arachnoid mater
Acute < 3 days
Subacute 3-21 days
Chronic > 21 days

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14
Q

Pathophysiology of subdural haematoma

A

Bleeding occurs due to shearing forces on corticla bridging veins with sudden change in velocity of head
Normally due to trauma
- may be spontaneous in anticoagulated patients

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15
Q

Presentation of subdural haematoma

A

Headache
Acute - severely depressed GCS, pupillary abnormalities
Chronic - insidious onset of confusion and cognitive decline

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16
Q

Ix for subdural haematoma

A

CT scan

  • bleed does not cross midline due to falx cerebri
  • banana shape
  • midline shift away from bleed
  • loss of cerebral architecture on affected side
  • chronic bleed appears darker
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17
Q

Mx of subdural haematoma

A

Prognosis relatively poor - full recovery in 20% of patients
Small chronic - serial imaging to monitor progression
Acute - neurosurgical intervention to relieve raised ICP

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18
Q

Define stroke

A

Sudden onset of focal neurological deficit due to vascular cause

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19
Q

Types of strokes

A
Haemorrhagic - vascular rupture
- intracerebral
- subarachnoid
- subdural
Ischaemic - vascular occlusion or stenosis
20
Q

Types of haemorrhagic strokes

A

Lobar
- cortex or subcortical white matter of cerebral hemispheres
Deep hemispheric
- supratentorial deep grey matter structures
- most commonly putamne and thalamic nuclei
Brain stem
- mainly pons
Cerebellar
- mostly dentate nucleus

21
Q

Classification of ischaemic strokes

A

TOAST classification
Large artery atherosclerosis
- infarction in perfusion of extracranial or intracranial artery with > 50% stenosis
Cardioembolism
- infarction in presence of one cardiac condition
- AF
Small vessel occlusion
- infarction < 1.5cm in diameter in perfusion territory of small penetrating blood vessel
Stroke of other determined aetiology
- vasculitis, arterial dissection, hypercoagulable states
Stroke of indeterminate aetiology

22
Q

Epidemiology of stroke

A

3rd leading cause of death and major disability
180 per 100,000
Ischaemic = 87%

23
Q

Risk factors for stroke

A
Older age
Fhx
PMHx
Hypertension
Smoking
DM
AF
Comorbid cardiac conditions 
- MI, decreased left VEF, valvular disease, cardiomyopathy
Carotid artery stenosis
Sickle cell disease
Dyslipidaemia
Obesity
Alcohol abuse
Oestrogen-containing therapy 
Illicit drug use
Migraine
Hypercoagulable state
Haemophilia
Anticoagulation
24
Q

Pathophysiology of stroke

A

Ischaemic
- blood supply in cerebral vascular territory critically reduced
- thrombosis risk increased by Virchow’s triad
Haemorrhagic
- vascular rupture with bleeding into brain parenchyma
- expanding haematoma may shear neighbouring arteries -> futher bleeding
- mass effect -> increased ICP, reduced cerebral perfusion, ischaemic injury

25
Presentation of stroke
``` Visual loss or visual field deficit - commonly in patients with posterior circulation ischaemia - unilateral - carotid or vertebrobasilar ischaemia - bilateral - vertebrobasilar ischaemia Weakness - complete or partial loss of muscle strength in face/arms/kegs - all three suggests deep hemispheric involvement Aphasia - expressive or receptive Ataxia - cerebellar pathology Sudden onset Diplopia Sensory loss Dysarthria Gaze paresis Neck pain Miosis, ptosis facial anhidrosis Altered level of consciousness Photophobia and headache ```
26
Define stroke chameleons
Presentations which resemble other conditions but are actually stroke Venous infarcts - impaired drainage and gradual onset Small cortical strokes - peripheral nerve lesions Limb shaking TIA Occipital stroke - present with confusion and delirium - visual field defects
27
Ix for stroke
``` Non-enhanced CT - within 1 hour - ischaemic - CT normal in first few hours, hyperattenuation of relevant vessel due to clotted blood, loss of grey-white matter differentiation, hypodensity of cortical tissue - haemorrhagic - hyperdense lesion CT with contrast angiography - if thrombectomy indicated CT perfusion imaging or MRI alternative Serum glucose - exclude hypogylcaemia Serum electrolytes Urea + creatinine - renal failure may be contraindication to mx Cardiac enzymes - concomitant MI ECG - exclude arrhythmia or ischaemia FBC Clotting screen Carotid USS - carotid stenosis ```
28
Oxford classification of ischaemic strokes
Total Anterior Circulation Stroke - TACS - usually cardiac emboli - affects area of brain supplied by middle and anterior cerebral arteries Partial Anterior Circulation Stroke - PACS - usually large vessel disease - less severe form or TACS Posterior Circulation Syndrome - POCS - involves damage to area of brain supplied by the posterior circulation - occipital lobe, cerebellum or brainstem Lacunar Syndromes - LACS - usually atheroma in situ - subcortical stroke that occurs secondary to small vessel disease - no loss of higher cerebral functions
29
Classification of Total Anterior Circulation Stroke
All 3 must be present - unilateral weakness of face, arm and leg - homonymous hemianopia - higher cerebral dysfunction - dysphasia, visuospatial disorder
30
Classification of Partial Anterior Circulation Stroke
2 of the following present - unilateral weakness of face, arm and leg - homonymous hemianopia - higher cerebral dysfunction - dysphasia, visuospatial disorder
31
Classification of Posterior Circulation Syndrome
One of the following - cranial nerve palsy and contralateral motor/sensory deficit - bilateral motor/sensory deficit - conjugate eye movement disorder - horizontal gaze palsy - cerebellar dysfunction - vertigo, nystagmus, ataxia - isolated homonymous hemianopia
32
Classification of Lacunar Syndrome
One of the following present - pure motor stroke - lenticulostriate artery - pure sensory stroke - thalamoperforator artery - sensorimotor stroke - ataxic hemiparesis
33
Assess the severity of stroke
``` National Institutes of Health Stroke Scale Level of consciousness o Level of alertness (0-3) o Verbal (0-2) o Visual and motor (0-2) · Best gaze (0-2) · Visual fields (0-3) · Facial Palsy (0-3) · Arm motor (0-4) · Leg motor (0-4) · Limb ataxia (0-2) · Sensory (0-2) · Best language (0-3) · Dysarthria (0-2) · Extinction and inattention (neglect) (0-2) 0 – no stroke symptoms 1-4 – minor stroke 5-15 – moderate stroke 16-20 – moderate to severe stroke 21-42 – severe stroke ```
34
Define ROSIER
Used in A+E for stroke diagnosis
35
Stages of ROSIER
Exclude hyperglycaemia first Loss of consciousness or syncope = -1 Seizure activity = -1 New, acute onset of asymmetrical face weakness = +1 New, acute onset of asymmetrical arm weakness = +1 New, acute onset of asymmetrical leg weakness = +1 New, acute onset of speech disturbance = +1 New, acute onset of visual field defect = +1 A stroke is likely if the score is > 0
36
Mx of ischemic stroke
``` Emergency - IV alteplase - thrombectomy Conservative - admission to stroke unit to optimise physiology and monitor Medical - aspirin 300mg daily for 2 weeks - clopidogrel 75mg TD after aspirin finished Surgical - carotid endarterectomy ```
37
How does alteplase work
Activates plasminogen to form plasmin | - degrades fibrin and breaks up thrombi
38
Indications for alteplase
Clinical diagnosis of ischaemic stroke - NIHSS 4 - aphasia - binocular visual field deficit - swallowing deficit - unable to walk or self-care independtly
39
Absolute contraindications for alteplase
``` BP > 185/110 after 2 attempts to reduce Surgery or trauma within last 14 days Active internal bleeding Haematology abnormalities - INR>1.7 or APTT > 40 Arterial puncture at non-compressible site or LP in last 7 days Symptoms of subarachnoid haemorrhage IE, pericarditis Childbirth in last 4 weeks Acute pancreatitis Severe liver disease ```
40
Conservative mx of stroke
``` Admission to stroke unit to optimise physiology - Maintain good glycaemic control - Ensure BP doesn't drop - Ensure good sleep - Monitor O2 sats - Nutritional support - Rehabilitation Lifestyle modifications - Smoking - Weight - Alcohol - Diet - Exercise ```
41
Mx of underlying stroke pathologies
``` Anticoagulation if has AF - balance bleeding and clot risk - CHADVASC - warfarin - HASBLED - DOACs Antihypertensives - target of 130/80 - ACE inhibitors - CCB - Thiazides Statins for hypercholesterolaemia Glycaemic control for diabetes ```
42
Mx of haemorrhagic stroke
``` Neurosurgical evaluation Airway protection Blood pressure control - labetalol - nicardipine ```
43
Complications of stroke
``` Dysphagia may lead to aspiration Prolonged immobility - DVT - Pressure ulcers - Constipation - urinary retention Seizures - abnormal glial activity Recurrent strokes Raised ICP - malignant oedema - hydrocephalus - haemorrhagic transformation Cognitive issues Mood changes Fatigue Pain Alteplase-related orolingual oedema ```
44
Features of TIA
Symptoms lasting less than 24 hours | Refer to TIA clinic within 24 hours
45
Screen for subsequent stroke post TIA
ABCD2 score - A - age > 60 - B - blood pressure > 140/90 - C - clinical features - unilateral weakness = 2, dysphasia without weakness = 1 - D - duration - >60mins = 2, 10-60mins = 1 - D - diabetes
46
Mx of TIA
< 3 = specialist assessment within week > 3 = specialist assessment in 24 hours Start aspirin 300mg OD and simvastatin 40 mg OD