Stroke Flashcards
(46 cards)
Define subarachnoid haemorrhage
Bleeding into the subarachnoid space
- between the arachnoid mater and pia mater
Epidemiology of subarachnoid haemorrhage
6-8 cases per 100,000
Average onset 50-55
Higher incidence in men and black people
Risk factors for subarachnoid haemorrhage
Hypertension
Smoking
FHx
Autosomal dominant polycystic kidney disease
Pathophysiology of subarachnoid haemorrhage
Most commonly spontaneous rupture of berry aneurysms - commonly in the anterior circle of Willis
AV malformation
Arterial dissections
Use of anticoagulants
Presentation of subarachnoid haemorrhage
Sudden onset, thunderclap headache Photophobia Loss of consciousness CN III palsy - posterior communicating artery aneurysm compressing the ipsilateral CN III N+V Meningism
Ix for subarachnoid haemorrhage
CT head - hyperdense areas in basal cisterns, major fissures and sulci
FBC - leucocytosis
Clotting profile - may show coagulopathy - elevated INR, prolonged PTT
Troponin I - elevated in 1/4 of cases
LP - presence of RBCs or xanthochromia in 3 consecutive samples
Mx of subarachnoid haemorrhage
Cardiopulmonary support
- intubation, mechanical ventilation and sedation with benzodiazepines
- labetalol to keep systolic BP < 160
Surgical clipping/coil embolisation
Calcium channel blockers - vasospasm prophylaxis
Define extradural haemorrhage
Collection of blood between inner surface of skull and periosteal dura mater
Usually secondary to traum / skull fracture
Presentation of extradural haemorrhage
Loss of consciousness normally followed by transient recovery with ongoing headache
- caused by striping of dura from bone by expanding haemorrhage
Rapidly decreasing consciousness - haematoma enlarges increasing ICP
CN palsies - brain structures herniate
Ix for extradural haemorrhage
CT scan - bleeding limited by suture lines of skull
- hyperdense lemon shape
- midline shift away from bleed
- compression of ventricles
Mx of extradural haemorrhage
Prognosis good with early intervention
A-E assessment and neuro exam
Small - observe and manage conservatively
Large - urgent referral to neurosurgery for craniotomy and clot evacuation
Complications of extradural haemorrhage
Permanent brain damage Coma Seizures Weakness Pseudoaneurysm Arteriovenous fistula formation
Define subdural haematoma
Collection of blood between meningeal dura mater and arachnoid mater
Acute < 3 days
Subacute 3-21 days
Chronic > 21 days
Pathophysiology of subdural haematoma
Bleeding occurs due to shearing forces on corticla bridging veins with sudden change in velocity of head
Normally due to trauma
- may be spontaneous in anticoagulated patients
Presentation of subdural haematoma
Headache
Acute - severely depressed GCS, pupillary abnormalities
Chronic - insidious onset of confusion and cognitive decline
Ix for subdural haematoma
CT scan
- bleed does not cross midline due to falx cerebri
- banana shape
- midline shift away from bleed
- loss of cerebral architecture on affected side
- chronic bleed appears darker
Mx of subdural haematoma
Prognosis relatively poor - full recovery in 20% of patients
Small chronic - serial imaging to monitor progression
Acute - neurosurgical intervention to relieve raised ICP
Define stroke
Sudden onset of focal neurological deficit due to vascular cause
Types of strokes
Haemorrhagic - vascular rupture - intracerebral - subarachnoid - subdural Ischaemic - vascular occlusion or stenosis
Types of haemorrhagic strokes
Lobar
- cortex or subcortical white matter of cerebral hemispheres
Deep hemispheric
- supratentorial deep grey matter structures
- most commonly putamne and thalamic nuclei
Brain stem
- mainly pons
Cerebellar
- mostly dentate nucleus
Classification of ischaemic strokes
TOAST classification
Large artery atherosclerosis
- infarction in perfusion of extracranial or intracranial artery with > 50% stenosis
Cardioembolism
- infarction in presence of one cardiac condition
- AF
Small vessel occlusion
- infarction < 1.5cm in diameter in perfusion territory of small penetrating blood vessel
Stroke of other determined aetiology
- vasculitis, arterial dissection, hypercoagulable states
Stroke of indeterminate aetiology
Epidemiology of stroke
3rd leading cause of death and major disability
180 per 100,000
Ischaemic = 87%
Risk factors for stroke
Older age Fhx PMHx Hypertension Smoking DM AF Comorbid cardiac conditions - MI, decreased left VEF, valvular disease, cardiomyopathy Carotid artery stenosis Sickle cell disease Dyslipidaemia Obesity Alcohol abuse Oestrogen-containing therapy Illicit drug use Migraine Hypercoagulable state Haemophilia Anticoagulation
Pathophysiology of stroke
Ischaemic
- blood supply in cerebral vascular territory critically reduced
- thrombosis risk increased by Virchow’s triad
Haemorrhagic
- vascular rupture with bleeding into brain parenchyma
- expanding haematoma may shear neighbouring arteries -> futher bleeding
- mass effect -> increased ICP, reduced cerebral perfusion, ischaemic injury