Strongyles 2 Flashcards

1
Q

You find strongyle-type eggs in a foal less than 6 weeks old. What do you suspect?

A

The foal probably swallowed ingested mare feces, and the eggs are just passing through the GI tract.

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2
Q

You find strongyle-type eggs in a foal >6wks but <6mo old. What do you suspect?

A

Likely a small strongyle infection.

Recall that the minimum pre-patent period for large strongyles is 6 months.

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3
Q

You find strongyle-type eggs in a foal older than 6 months. What type of infection do you suspect?

A

Probably a mixture of large and small strongyles.

Impossible to differentiate between large and small strongyle eggs grossly. To distinguish the two, you can allow the larvae to hatch or run a PCR.

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4
Q

What is the scientific term for a small strongyle infection?

A

Cyathostomiasis

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5
Q

Which are more susceptible to anthelmintics: large strongyles or small strongyles?

A

Large strongyles.

Resistance to anthelmintics is an increasing problem in small stronglyes.

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6
Q

Name 3 common genera of small strongyles.

A
  • Cyathostomum*
  • Cylicocyclus*
  • Cylicostephanus*
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7
Q

Which small strongyle life stage is infective? Describe this stage.

A

L3

This stage is free-living on vegetation and retains the sheath from the previous molt.

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8
Q

What happens to the L3 cyathostome larva once it is swallowed by the equine host?

A

Sheds its sheath, burrows into the mucosa, molts to L4 larva.

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9
Q

What factors can contribute to clinical disease in a horse with a small strongyle infection?

A

Crowding, poor nutrition, poor worming program, etc.

For example, if a horse has bad teeth and is not able to obtain proper nutrition, it is more likely to show signs of disease when infected with small strongyles.

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10
Q

What are the clinical signs associated with a small strongyle infection in horses?

A

Weight loss or decreased weight of gain

Generalized debility/poor doer

Retention of winter hair coat

May have diarrhea, but not necessarily

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11
Q

How would you diagnose a small strongyle infection

A

Age

Clinical signs

Large numbers of strongyle-type eggs in the feces

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12
Q

What is larval cyathostomiasis?

A

Clinical syndrome caused by mass emergence of larvae from their mucosal cysts. Causes a massive insult to the gut wall.

Often seen in spring when large numbers of hypobiotic larvae emerge.

Not seen in every small strongyle infection.

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13
Q

What is a potential concern of quickly killing adult cyathostomes in an equine gut with anthelmintics?

A

Rapid decline in adult numbers may cause a mass emergence of hypobiotic larvae, resulting in larval cyathostomiasis.

Usually occurs within 2 weeks of treatment.

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14
Q

What are the clinical symptoms associated with larval cyathostomiasis?

A

Acute onset of fever

Persistent diarrhea (may contain blood and mucus)

Hypoalbuminemia, neutrophilia, hyperglobulinemia

Severe weight loss

Potentially fatal

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15
Q

A horse is showing signs of larval cyathostomiasis. How do you diagnose it?

A

Unfortunately, this is usually done at necropsy.

Because the disease results from LARVAL emergence, you usually cannot detect eggs in the feces.

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16
Q

How do you treat larval cyathostomiasis?

A

Anthelmintic:

Moxidectin

Supportive care:

anti-diarrheal drugs

corticosteroids to decrease inflammation

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17
Q

You detect cyathostomes in your horse herd. DEWORM. DEWORM EVERYTHING.

Right?

A

Chill out, bro.

Strategic deworming should be planned on a farm-by-farm basis.

Take into account which horses are showing signs, sanitation, and husbandry practices.

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18
Q

What are the main goals of SELECTIVE THERAPY in strongyle control?

A
  1. Control populations in order to avoid clinical signs (i.e. reduce eggs on the pasture).
  2. Control/slow the development of resistance.
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19
Q

What husbandry measures can you implement to help control equine strongyles?

A

Remove vegetation growing in paddocks

Feed dry feed only

Keep horses on a sound nutritional program

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20
Q

Which two major observations is the concept of selective therapy reliant on?

A

Parasites are unevenly distrubeted (overdispursed)

Stroyngyle egg shedding adult horses is consistent over time

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21
Q

True or False:

If a horse infected with strongyles is a high egg-shedder, it will remain a high egg-shedder over time.

A

TRUE

Egg shedding over time tends to remain consistent in adult horses.

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22
Q

What are refugia in parasite populations?

A

Hosts that have been left untreated in order to maintain parasite genes that remain susceptible to anthelmintics.

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23
Q

What happens if you treat an entire population with anthelmintics? Why are refugia important?

A

Treating an entire population will allow only resistant parasites to survive. Leaving some animals untreated leaves resistance genes in the population.

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24
Q

What is cross-resistance?

A

Parasites resistant to one drug in an anthelmintic class are usually resistant to all drugs in that class.

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25
Q

Describe the 80/20 rule

A

20% of horses in a population shed 80% of the parasite eggs.

Remember that parasites are unevenly distributed (overdispersed)

26
Q

What is the suggested theshold for egg content in the feces of horses in order to approve treatment?

A

200 eggs per gram (EPG)

27
Q

What test would you use to detect eggs in the feces?

A

Fecal float

28
Q

What test would you use to quantify the number of eggs in a fecal sample?

A

McMaster chamber

29
Q

What test would you use to determine whether your treatment is reducing the parasite load in a host?

A

Fecal Egg Count Reduction Test (FECRT)

30
Q

What is the formula for FECRT?

A

(EPG pre-treatment) - (EPG 14 days post-treatment) x 100

(EPG pre-treatment)

31
Q

Should you use selective therapy on young horses?

A

Lol nope

Only for use in adult horses

32
Q

What is the egg reappearance period (ERP)?

A

Time interval between last effective anthelmintic treatment and the resumption of egg shedding

33
Q

Cyathostomes show widespread resistance to which class of drugs?

A

Benzimidazoles

34
Q

Parascaris shows widespread resistance to which class of drugs?

A

Macrocyclic lactones

35
Q

Based on their respective resistances, which drugs should you use to treat cyathostomes, and which drugs should you use to treat Parascaris?

A

Cyathostomes - macrocyclic lactones

Parascaris - benzimidazoles

36
Q

Describe the deworming schedule for a newborn horse

A

4 treatments total

Treatments 1 and 2 - benzimidazoles to control ascarids

  • at 3 months, 6 months

(At this point, check FEC to monitor parasite loads)

Treatments 3 and 4 - macrocyclic lactones to control strongyles

  • at 9 months, 12 months
37
Q

What kind of worm is Oesophagostomum sp.?

A

Nematode: True Strongyle

Nodular worm

38
Q

Name the four species of Oesophagostomum and the species they infect.

A
  • O. radiatum*: cattle
  • O. columbianum*: cattle
  • O. venulosum*: small ruminants
  • O. dentatum*: pigs
39
Q

This is an adult Oesophagostomum radiatum. Identify the structures pointed to by the arrows.

A

Cephalic vesicle (right arrow)

Cervical vesicle (left arrow)

*These are out-foldings of the cuticle that wrap all the way around the worm.

40
Q

Where do adult Oesophagostomum live?

A

Large intestine

41
Q

What is the infective stage of Oesophagostomum?

What is the pre-patent period?

A

Sheathed L3

6-7 weeks

42
Q

What are the consequences of re-infection with Oesophagostomum?

A

Localized immune reaction around larvae in mucosa (nodules or mini-abscesses), mostly in large intestine.

43
Q

How long can Oesophagostomum larvae persist inside intestinal mucosal nodules?

A

Less than 3 months.

Worm larvae tend to get trapped in the nodules and die. Nodules will eventually caseate and calcify.

44
Q

What are the clinical signs associated with re-infection with Oesophagostomum?

A
  • Nodules interfere with peristalsis and absorption
  • Anorexia, weight loss, diarrhea, poor wool quality, etc.
  • Thin sow syndrome - chronic flare-ups due to hypobiotic emergence around farrowing
  • Nodules may rupture (rare)
    • If rupture into lumen: ulcerative colitis
    • If rupture out of serosa: peritonitis, adhesions, death
45
Q

True or False:

“Large-mouthed bowel worm” makes a great insult for when you get into bar fights.

A

True, I guess?

46
Q

What is the pre-patent period of Chabertia ovina?

A

6 weeks

47
Q

How many teeth does Chabertia ovina have?

A

None. None teeth.

48
Q

Identify this species found in a goat

A

Chabertia ovini

Note the large, bell-shaped buccal capsule with no teeth.

49
Q

Are there clinical signs associated with low-level Chabertia infections?

A

Meh.

You might see some diarrhea, local hemorrhage into the gut, and somesuch.

50
Q

Identify these adult worms found in the perirenal fat of a pig.

A

Stephanurus dentatus

Note the stout appearance with no lips (do not confuse for an ascarid). Poorly developed copulatory bursa.

Also, the host species and location of the worm was a pretty dead giveaway.

51
Q

What are the modes of infection with Stephanurus?

A

Ingestion of L3

Skin penetration by L3*

Ingestion of earthworm paratenic host carrying L3

*Editor’s note: Aaaah! AAAAHHH!

52
Q

Describe the life cycle of Stephanurus after it has been swallowed

A
  • Migrates from gut to liver. Lives there for usually 2-3 months.
    • Can cause extensive liver damage
  • Exits through liver capsule.
  • Migrates retro-peritoneally to kidney wall and ureters
  • Matures to adult in cysts
  • Lays eggs, which are excreted in the urine
53
Q

What is the pre-patent period of Stephanurus?

How long do the adults live?

A

9-16 months

2 years

54
Q

This is a liver lesion caused by Stephanurus dentatus larvae. Can you think of another worm that causes similar lesions?

A

Ascaris suum

55
Q

What are the clinical signs associated with Stephanurus larval migrations?

A

Skin lesions from penetration sites

Liver fibrosis, cirrhosis, abscesses, adhesions

Poor thrift, emaciation, death

Note: adults in renal tissues may be non-pathogenic

56
Q

You tech hands you a sample. A quick perusal under the scope reveals standard strongyle-type eggs.

Fantastic. There are, like, a bazillion species that fit that description.

Then your tech remembers that the sample came from the urine of a pig. What is your diagnosis?

A

Stephanurus dentatus

57
Q

These worms were found in the perirenal fat of a pig. What species is this?

A

Stephanurus dentatus

Note that when fixed, these worms will appear white, not red.

58
Q

Where do you usually find pigs with Stephanurus infections?

A

In pigs raised outdoors and in wild pigs.

Usually found in the SE US because of larval intolerance to cold.

59
Q

A farmer has this crazy idea that feeding his donkeys pig urine is an important first step in creating a pig-donkey hybrid, or “pigonkey.”

Needless to say, the farmer does not believe in deworming.

A few months after starting this madness, one of the donkeys starts showing signs of posterior paralysis. What do you think happened?

A

Stephanurus dentatus can cause larva migrans in accidental hosts.

On rare occasions, the worm can abberantly migrate to the CNS and cause posterior paralysis.

60
Q

What is the pre-patent period of Stephanurus dentatus?

A

~1 year

(very long pre-patent period)

61
Q

What control measures can you take to rid a pig population of Stephanurus infections?

A
  • Raise pigs on concrete or in confinement
    • Separate pigs from urine, L3 larvae, and earthworms
    • Eggs don’t survive well in cold or dry conditions
  • Use gilt-only breeding program for 3-4 generations
    • Breed at 7-8 months of age (shorter than the worm’s pre-patent period)
    • Sell female after first litter is weaned