Substance Use Disorder Pharmacology Dr. Iszard

Question 1

common abused depressants

Answer 1

Diazepam, Alprazolam, Citalopram, Zolpidem, Zaleplon

Question 2

common abused stimulants

Answer 2

adderal
dexedrine
methylphenidate
desoxyn
destrostat

Question 3

common abused pain killers

Answer 3

codeine
morphine
hydrocodone
oxycodone
Fentanyl

Question 4

Methamphetamine

1. type of drug
2. formulation
3. MOA

Answer 4

1. not perscribed drug however breaks down to amphetamine partially (which is seen in methylphenidate and dextamphetamines)
2. snorted, pill, injected
3. stimulant

Question 5

Cocaine

1. formulation
2. side effects
3. duration
4. MOA

Answer 5

1. injected, snorted, smoked,
2. paranoia, exhaustion and need to sleep and depression for days, organ damage
3. only lasts 15min then need to snort another one
4. inhibits DA reuptake

Question 6

Ketamine

1. MOA
2. formulation
3. side effects

Answer 6

1. hallucinogenic + anesthetic, schedule 3
2. injected, smoked, snorted, liquid
3. agitation, confusion, hallucinations, SEDATION

Question 7

Lysergic Acid Diethylamide

1. MOA
2. 2 common thing that happens (side effects)
3. formulation

Answer 7

1. hallucinogenic (LSD)
2. flashbacks months later (stored in adipose that can breakdown anytime), can uncover personality disorders (like stimulants, mushrooms, PCP)
3. oral paper

Question 8

opioid receptor antagonist

opioid addiction tx

Answer 8

Naloxone

Naltrexone

Question 9

Synthetic Opioid for opioid addiction tx

Answer 9

Methadone

Question 10

opioid addiction tx : partial u-opioid R agonist

Answer 10

Buprenorphine

Question 11

Nicotine Receptor partial agonist to tx nicotine addiction

Answer 11

Varenicline

Question 12

Benzodiazepines ued for addiction tx (like alcohol withdrawal, or opioid addiction)

Answer 12

1. Oxazepam

2. Lorazepam

Question 13

Dronabinol

Answer 13

tx marijuana addiction

Question 14

[revent alcohol misuse drugs

Answer 14

acamproste
disulfriam
naltrexone

Question 15

tx ethylene glycole poisoning (freeze liquid)

Answer 15

ethanol (alcohol)

fomepizole

Question 16

caffeine chemical that tx migraine headaches

Answer 16

Ergotamine

Ephedrine in high dose can be used instead of illegal substances

Question 17

Caffeine can increase what drug effect

Answer 17

painkillers like NSAIDS or acetominophen

Question 18

caffeine can help

Answer 18

OCD, ADHD, asthma, gallstones, mental impairments, memory, lung probs in newborn, hep C, stroke, cirrhosis, O2 in blood during exercise

Question 19

Naltrexone

1. used for and how long
2. moa
3. who

Answer 19

1. tx alcohol and opiate dependence (REDUCE CRAVINGS, 12 weeks)
2. u-opiate R antagonist
3. those who have stopped to avoid the acute WD effects

Question 20

Acamprosate

1. MOA
2. used for and how long

Answer 20

1. weak NMDA antagonist, GABAa agonist, (increase 5HT, NE, DA)
2. lowering relapse in short term and long term (6 months)

Question 21

ethylin and methanol and dangerous for what reasons

Answer 21

they go through alcohol dehydrogenase —-> Formaldehyde then by ALDEHYDE DEHYROGENASE** —-> Formic ACID (DANGEROUS)

* Alcohol (ethanol) goes through alcohol dehydrogenase and becomes Acetaldehyde (hangover sx) and then ALDEHYDE DEHYROGENASE –> ACETIC ACID (normal)

Question 22

Disulfiram

1. MOA
2. used for
3. causes what
4. make sure

Answer 22

1. Blocks Aldehyde dehydrogenase
2. alcohol dependence pts
3. EXTREME hangover and discomfort sx when they drink alcohol due to build up of acetaldehyde = VOMIT
4. dont give with any mouthwash, cough syrap, cold tx (that have alcohol)
   MAKE SURE PT is very motivated**