Substitution & Elimination Reagents

Question 1

NaCl

Answer 1

Dissociates into Cl- which is a strong nucleophile

Question 2

NaBr

Answer 2

Dissociates into Br- which is a strong nucleophile

Question 3

NaH

Answer 3

The hydride is a strong base that can be used in E2 reactions

Question 4

DBN and DBU

Answer 4

Strong bases that can be used in E2 reactions

Question 5

NaOH

Answer 5

Both a strong base and a strong nucleophile so it can be used for SN2 or E2 reactions depending on the substrate. (SN2 for primary, E2 for secondary and tertiary)

Question 6

NaOR

Answer 6

Both a strong nucleophile and a strong base so it can be used for SN2 and E2 depending on the substrate. ( SN2 for primary and E2 for secondary or tertiary)

Question 7

t-BuOK

Answer 7

Strong nucleophile and strong base but sterically hindered. This makes it flavor E2 for all levels of substitution. Favors formation of less substituted alkene

Question 8

NaSH

Answer 8

SH- is a strong nucleophile used in SN2 reactions

Question 9

H2O

Answer 9

Water is a weak nucleophile and a weak base that can be used in SN1 and E1 reactions. (With heat it will favor E1)

Question 10

ROH

Answer 10

Alcohols are weak nucleophiles and weak bases used in SN1 and E1. (Heat will favor E1). Can also serve as substrates for SN1/E1 under acidic conditions.

Question 11

HX

Answer 11

A strong acid that can serve as both an H+ source and a nucleophile as X-

Question 12

Conc. H2SO4

Answer 12

A strong acid used to convert alcohols into alkenes