Surgical diseases of the Pancreas Flashcards Preview

Block 11 module 6 > Surgical diseases of the Pancreas > Flashcards

Flashcards in Surgical diseases of the Pancreas Deck (46):
1

the body and tail of the pancreas lie anterior to the

splenic artery and vein

2

Chief excretory channel

Duct of Wirsung

3

accessory duct

duct of santorini

4

Blood supply to the pancreas comes from multiple
branches from the _____ and _____

celiac and superior mesenteric
arteries

5

artery that supplies the body and tail of the pancreas

splenic artery

6

arteries that supply the head of the pancreas

superior and inferior pancreaticoduodenal artery

7

stimulates endocrine and exocrine secretion

parasympathetic

8

inhibits secretion

sympathetic system

9

responsible for exocrine secretion

acinar cells

10

Responsible for endocrine secretion

Islet cells

11

Hydrolyzes starch and glycogen to glucose, maltose,
maltotriose and dextrins

PANCREATIC AMYLASE

12

missense mutation on the cationic trypsinogen, or
PRSS1, results

premature, intrapancreatic
activation of trypsinogen

13

Activated to form chymotrypsin.

CHYMOTRYPSINOGEN

14

Secreted by the pancreas as a proenzyme that
becomes activated by trypsin.

PHOSPHOLIPASE A2

15

function of phospholipase A2`

Hydrolyzes phospholipids and, as with all lipases,
requires bile salts for its action

16

Hydrolyze neutral lipid substrates like esters of
cholesterol, fat-soluble vitamins, and triglycerides

CARBOXYLIC ESTER HYDROLASE AND
CHOLESTEROL ESTERASE

17

fxn of CARBOXYLIC ESTER HYDROLASE AND
CHOLESTEROL ESTERASE

Hydrolyze neutral lipid substrates like esters of
cholesterol, fat-soluble vitamins, and triglycerides

18

secrete glucagon

alpha cells

19

secrete insulin

β-cells

20

secrete somatostatin

delta cells

21

secrete ghrelin

epsilon cells

22

secrete PP

PP cells

23

function of insulin

Inhibits glycogenolysis, fatty acid breakdown, and
ketone formation, and stimulates protein synthesis

24

major stimulant of somatostatin

intraluminal fat

25

Release is stimulated by hypoglycemia, and by the
amino acids arginine and alanine

GLUCAGON

26

glucagon release is stimulated by

hypoglycemia, and by the
amino acids arginine and alanine

27

most important role of pancreatic polypeptide

glucose regulation through its
regulation of hepatic insulin receptor gene expression

28

most potent enteral stimulator of PP release

protein

29

function of amylin

modulation or counterregulation of insulin
secretion and function

30

Inhibits insulin, and possibly somatostatin release, and
augments glucagon release
• Inhibits pancreatic exocrine secretion

PANCREASTATIN

31

Stimulates growth hormone secretion via growth
hormone releasing hormone release from the pituitary

GHRELIN

32

classification of Pancreatic true cysts

1. IPMN (intraductal papillary mucinous neoplasms)
2. SCN (Serous Cystadenoma)
3. MCN ( Mucinous Cystic Adenoma)

33

most commonn type of precancerous cyst

IPMN

34

3 clinical problems of pancreatic ductal adenocarcinoma

pain
jaundice
duodenal obstruction

35

a collection of enzyme rich pancreatic juice that occurs early in the course of acute pancreatitis, or that forms after a pancreatic duct leak; located in or near the pancreas; it lacks a well organized wall of granulation or fibrous tissue

peripancreatic fluid collection

36

A focal or diffuse area of nonviable pancreatic parenchyma, typically occupying > 30% of the gland and containing liquefied debris and fluid

Early pancreatic (sterile) necrosis

37

an organized collection of sterile necrotic debris and fluid with a well defined margin or wall within the normal domain of the pancreas

late pancreatic (sterile) necrosis

38

a collection of pancreatic juice enclosed within a perimitere of early granulation tissue, usually as a consequence of acute pancreatitis that has occured within the preceding 3-4 weeks

acute pseudocyst

39

pancreatic fluid collection in which gross purulence (pus) is present, withh bacterial or fungal organisms documented to be present

pancreatic abcess

40

a collection of pancreatic fluid surrounded by a wall of normal granulation and fibrous tissue, usually persisting for >6 weeks

chronic pseudocyst

41

etiology of chronic pancreatitis

Toxic Metabolic
Ideopathic
Genetic
Autoimmune
Recurrent acute and severe
Obstruction

42

2 minimally invasive interventions for acute pancreatitis

video assissted retroperitoneal debridement
endoscopic transgastric neurosectomy

43

surgical interventions for necrotizing pancreatitis

percutaneous drainage
endoscopic neurosectomy
combined percutaneous and endoscopic
laparoscopic transabdominal debridement
open debridement
transgastric approach

44

clinical feautre of mild acue pancreatitis according to classification of seveity

no organ failure
no local symptoms

45

clinical feautre of moderate severe pancreatitis according to classificate of seveity

Transient organ failure
(resolves in 48hrs)
Local or systemic
complications without
persistent organ failure

46

clinical feautre of severe acute pancreatitis according to classificate of seveity

Persistent organ failure
involving 1 or more
organs (>48hrs)