Surgical Infections Flashcards

1
Q

What is a surgical infection

A

They are infections that occur as a result of a surgical procedure or those that require surgical intervention as part of their treatment

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2
Q

What characterizes a surgical infection

A

A breach of mechanical/anatomic defence mechanisms (barriers)

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3
Q

Pathogens of surgical infections are usually ………… and …………..

A

Mixed, generally originate from patient’s endogenous flora

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4
Q

What are some factors associated with increase in the number of serious surgical infections

A

Performance of more complicated and longer surgeries
Increase in the number of geriatric patients
Use of implants
Increased use of immunosuppressive drugs
Laxity of aseptic techniques
Unwarranted reliance on prophylactic antibiotics

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5
Q

What are the classifications of a surgical site infection

A

Superficial
Incision deep
Organ space

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6
Q

A superficial incisional SSI occurs in which parts of the body

A

Skin
Subcutaneous tissue

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7
Q

A deep incisional SSI occurs in which part of the body

A

Deep soft tissue (fascia and muscle)

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8
Q

What are some things that could be done to prevent SSIs

A

Aseptic technique
Proper use of prophylactic antibiotics
Maximizing patients ability to prevent infection
Local wound factors
(i. Good judgement/surgical technique
ii. appropriate tissue handling
iii. debridement
iv. avoiding foreign bodies
v. adequate wound dressing
Patient related managing underlying (DM, uremia, obesity, malnutrition etc)

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9
Q

What are the treatments of SSIs

A

Source control; drainage of infected area
Deep/organ space – surgical drainage (open or percutaneous) +/- therapeutic antibiotics

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10
Q

Mention some types of specific surgical infections

A

Non necrotizing soft tissue infections
Necrotizing soft tissue infections

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11
Q

What is a non necrotizing soft tissue infection

A

It is an infectious process characterized by a necrotic center without supply

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12
Q

What are some characteristics of a non necrotising soft tissue infection

A

There is an abscess:
Infectious process characterised by a necrotic centre without blood supply
Composed of debris from local tissues, dead and dying WBCs, plasma and bacteria
Cannot resolve on antibiotic therapy

There is cellulitis:
Soft tissue inflammation with intact blood
Marked by an acute inflammatory response, vessel congestion, endothelial leakage and PMN infiltration
Resolves on antibiotics

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13
Q

Some abscesses may present as cellulitis because of their anatomic locations disguised in anatomic locations where fibrous septa join skin and fascia. What are some of these abscesses

A

Perirectal abscess
Breast abscess
Carbuncles
Felons

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14
Q

What are the characteristics of necrotising soft tissue infections

A

Gas gangrene/necrotising fasciitis
Involve deep subcutaneous tissue, deep fascia, muscle or a combination
Characterized by absence of clear local boundaries or palpable limits
Overlying skin has a relatively normal appearance in the early stages
Presence of gas on palpation (crepitus) grave sign
Diagnostic challenge in diabetic foot, obese
Overt signs of systemic compromise and septic compromise is seen in advance stages

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15
Q

What is the treatment of necrotizing soft tissue infections

A

Mainstay is debridement, it may be repeated
Broad spectrum antibiotics
Monitoring
Systemic support
?Hyperbaric O2
Anti toxins
Fungal pathogens have been implicated in NSTI

Typical intraoperative findings consistent with NSTI include
A dishwater-like exudate, dusky tissues, thrombosed vessels, lack of clear boundaries allowing finger dissection to spread through the compromised plane abnormally easily

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16
Q

What is a good predictor of outcome in a retroperitoneal or abdominal infection

A

APACHE score

17
Q

What are some characteristics of. Intrabdominal/retroperitoneal infections

A

Usually require surgical intervention for resolution (except SBP, amoebic liver abscess, salpingitis)
Outcome improved by early diagnosis and treatment
APACHE score good predictor of outcome

Mortality still high 5-50%

18
Q

Talk about prosthetic device related infection

A

Increased use of prosthesis
Presence of foreign materials impairs host defences
Allows certain bacteria with specific virulence factors (S. epidermidis) to stick

19
Q

What are some treatments to prosthetic device related infection

A

Intensive antibiotic therapy
Removal of prosthetic material
Removal under antibiotic cover and replacement

20
Q

What is the goal of antibiotics in surgical infections

A

Goal of antibiotic therapy is to achieve antibiotic levels at site of infection that exceed the MIC for the pathogen. Most antibiotics are started intravenously. Patients must be reviewed daily

21
Q

When do you change an antibiotic in a surgical infection

A

If no improvement after 3 days:
Initial operative procedure was not adequate
Initial procedure was adequate but a complication has occurred
A superinfection has developed at a new site
Drug choice is correct but not enough is being given
Another drug or different drug is needed
NB: Choice of antibiotics is the most common cause of treatment failure

22
Q

When do you stop antibiotics in a surgical infection

A

For most surgical infections, no specific duration is ideal
Role of ABS is to support local host defenses
3-5 days after I&D, local responses of new capillary formation, inflammatory exudate provide adequate local defense
General rule – continue ABS until clinical improvement and temp is stable for 48hrs
Do not send a patient home on oral antibiotics when the patient does not need it

23
Q

How do you prevent antibiotic resistance

A

Definitely multidisciplinary
Guidelines in antibiotic use
-Hospital formulary restriction
-Use of narrow spectrum antibiotics
-Antibiotic cycling
-Use of new antibiotics
Assessment of infection risk and quantitative culture
Area specific antibiotic use (OPD vs Inpatient)
Prevention of hospital transmission (hand washing, barrier nursing)