Sweatman: drugs and the blood

Question 1

Neonates bind drugs less or more than adults?

Answer 1

less

Question 2

most common human enzyme defect?

Answer 2

G6PD deficiency

Question 3

Mechanism of G6PD deficiency?

Answer 3

Basically, the cell is unable to protect itself from oxidative damage by H2O2 (G6PD initiates a cascade that results in the reduction of H2O2 via glutathione peroxidase)

Question 4

Most common clinical consequence of a G6PD deficiency?

Answer 4

drug-induced hemolysis

Question 5

Increased cytosolic calcium activity can lead to?

Answer 5

eryptosis

Question 6

most common cause of peripheral blood cytopenia?

Answer 6

myelosuppression

Question 7

a result of cytotoxic chemotherapy for neoplasia?

Answer 7

myelosuppression

Question 8

myelosuppression leads to?

Answer 8

decreased immune system and increased risk of infections

Question 9

this drug inhibits the activation of clotting factors II (thrombin), VII, IX, and X

Answer 9

warfarin

Question 10

this drug inhibits II (thrombin) and X?

Answer 10

heparin

Question 11

degrades fibrin thus inhibiting clot formation

Answer 11

plasmin

Question 12

induces erythropoetin

Answer 12

hypoxia