Sweatman Miscellaneous Drugs

Question 1

Drugs that act in the Vasomotor of the brain

Answer 1

clonidine, guanbenz, ganfacine, methyldopa

Question 2

Drugs that work in the sympathetic nerve terminals of peripheral tissues

Answer 2

resperine

Question 3

Alpha 2 agonists

Answer 3

clonidine guanabenze ganfacine *reduce sympathetic nervous system outflow

Question 4

alpha 2 agonist prodrugs

Answer 4

methyldopa

Question 5

NE storage depletion

Answer 5

resperine

Question 6

in tx of pheochromocytoma

Answer 6

metryosine–>depletion of NE

Question 7

alpha and beta receptors are

Answer 7

GPCR’s

Question 8

constant stimulation of alpha receptors by catecholamine stimulation leads to

Answer 8

DOWNREGULATION (endocytosis) of the alpha 2 receptors–>this does not happen in occasional –>stimulation –>loss of drug activity upon these receptors

Question 9

alpha 2 receptors are

Answer 9

autoreceptors–>take back up NE causing inhibition of further release of NE (negative feedbacker)

Question 10

what defines a heteroreceptor

Answer 10

expression of adrenergic alpha2 receptor in non-cholinergic tissues?

Question 11

sedation, analgesia, bradycardia, hypotension caused by alpha 2 agonists caused by

Answer 11

agents acting on heteroreceptors in the post synaptic neuron

Question 12

how do alpha 2 agonists lower BP

Answer 12

cross BBB and work centrally to increase flow in the periphery, while in periphery they constrict–>therefore the central impact is greater than the peripheral effect

Question 13

alpha 2 agonists that cannot cross the BBB

Answer 13

cannot effectively lower BP

Question 14

IS THERE REFLEC TACHYCARDIA WITH ALPHA 2 AGONISTS

Answer 14

NO, HR MAY REDUCE BC OF VAGAL STIMULATION

Question 15

ARE ALPHA 2AGONISTS USEFUL IN DIABETICS

Answer 15

YES–>NO EFFECT ON BLOOD GLUCOSE

Question 16

METHYLDOPA AND IRON CHELATORS

Answer 16

–>CHELATES METHYLDOPA TOO MUST SEP. DOSING INTERVAL

Question 17

METHYLDOPAAND RENAL FAILURE–

Answer 17

MUST RAISE DOSE

Question 18

ADVERSE EFFECTS OF ALPHA 2 AGONISTS

Answer 18

DROWSINESS–> GIVE QHS DRY MOUTH–>CARIES ABDOMINAL PAIN CONSTIPATION IMPOTENCE DEC LIBIDO

Question 19

METHYLDOPA INTERFERES WITH

Answer 19

CAECHOLAMINE QUANTITATION -CONTRAINDICATED IN PHEOCHROMOCYTOMA

Question 20

CLASS B ALPHA 2 AGONISTS

Answer 20

METHYLDOPA GANFACINE *MOST PERMISSIVE

Question 21

drug that can be used safely in pregnancy

Answer 21

methyldopa–>drug of choice labetolol metoprolol nefedipine

Question 22

Reserpine MOA

Answer 22

inhibits VMAT2 –>depletion of catecholamine in presynaptic terminals ->lost capacity to conecntrate and store NE and dopamine *no mature NE vessicles

Question 23

pharmacologic sympathectomy

Answer 23

Reserpine causes catecholamines leak into cytoplasm and are metabolize

Question 24

toxicity of reserpine

Answer 24

CNA–>sedation, increased suicidal rates

Question 25

reserpine contraindicated in

Answer 25

PUD or ulcerative colitis --\>avoid in pregnancy and breast feeding