Sweatman Testiclular Cancer Drugs Flashcards Preview

Reproductive > Sweatman Testiclular Cancer Drugs > Flashcards

Flashcards in Sweatman Testiclular Cancer Drugs Deck (27):
1

class of drugs for testicular cancer

Classical Cytotoxic agents

2

cancer is found in only the testis

stage one

3

cancer in lymph nodes in the abdomen

stage 2

4

cancer beyong lymph nodes and in the abdomen

stage 3

5

may be cancer in parts of the body far away from the testicles (lungs and liver)

stage 3

6

most common solid tumor in men between 15-34 years old

testicular cancer

7

one of the most chemo-sensitive and thus curative cancers

testicular cancer

8

95% of testicular cancers are...

germ cell tumors classified as seminomas or non-seminomas

9

serum tumor markers for testicular cancer

AFP
BetaHcg
LDH

10

early sign of testicular CA relapse

rise in plasma marker levels
*therfore must measure before during and after treatment and thru follow up

11

three PHASES of tx for testicular cancer

Sx
Radiotherapy
Chemo

12

primary CHEMO for testicular cancer

Etopo/Cisplastin
Bleo/Etopo/Cis
Etopo/Mesna/Ifosfamide/Cisplatin

13

second ling therapy for metatstic tumors

Vinblastine/mesna/Ifo/cis
>paclitaxel/mesna/ifo/cis

14

all treatment options for testicular cancer involve

platinum agent

15

high doe regimins involve what

peripheral stem cell infusions

16

must be igven with ifosfamide

mesna
-renoprotective, protects against hemorrhagic cystitis

17

dode limiting pulmonary fibrosis

bleomycin
(dna strand breakage)

18

dose limiting renal toxicity

cisplatin
-nuclaer and mitochondrial DNA-oxidative stress

19

dose limiting thrombocytopenia

same as cisplatin but slower and requires bigger dose

20

dose limiting leukopenia

etoposide

21

dose limiting myelosupresion

ifosfamide
alkylating agent-crosslinks

22

dose limiting bone marrow supression

paclitaxel
inhibits depolymerization of microtubules

23

doe limiting neuropathy

vinblastine
-disintegrates microtubules

24

forms acrolein thioester bonds which are inactive

MESNA

25

loss of sense of taste

MESNA

26

ototoxicity

cisplastin
carboplatin

27

used to prevent cisplatin toxicity

amifostine