swilm

Question 1

Causes of Glomerulonephritis Disease

Answer 1

1-Vascular Disease

2-Glomerular Disease

Question 2

what are the Vascular Disease that cause Glomerulonephritis Disease

Answer 2

1-Wegener granulomatosis (now called granulomatosis polyangiitis)
2-Churg-Strauss syndrome
3-Henoch-Schönlein purpura
4-Polyarteritis nodosa
5-Thrombotic thrombocytopenic purpura (TTP)
6-Hemolytic uremic syndrome (HUS)
7-Cryoglobulinemia

Question 3

what are the Glomerular Disease that cause Glomerulonephritis Disease

Answer 3

1-Goodpasture syndrome
2-Postinfectious glomerulonephritis
3-IgA nephropathy (Berger disease)
4-SLE
5-Idiopathic rapidly progressive
glomerulonephritis
6-Alport syndrome
7-Diabetes and hypertension
(most common causes)
8-Amyloid

Question 4

Wegener granulomatosis (WG) is characterized by

Answer 4

1-systemic vasculitis that most often involves the kidney, lung, and upper respiratory tract such as the sinuses or middle ear.
2-can also involve the skin (50%), joints, eyes (50%), and GI tract.

Question 5

If a patient with chronic upper and lower respiratory illness does not respond to antibiotics, consider

Answer 5

Wegener Granulomatosis

Question 6

The best initial test specific for Wegener granulomatosis

Answer 6

antiproteinase-3 antibody (or cytoplasmic antineutrophil cytoplasmic antibody
[C-ANCA]).

Question 7

Diagnosis of Wegener granulomatosis

Answer 7

• Lab abnormalities include elevated ESR, anemia, and leukocytosis.
• Rheumatoid factor is positive in 50% of patients.

Question 8

Complement levels are ……………in WG

Answer 8

normal

Question 9

The most accurate test is

Answer 9

a biopsy of the kidney, nasal septum, or lung, looking for granulomas.

Question 10

Treatment for WG is

Answer 10

cyclophosphamide and steroids.

Question 11

define Churg-Strauss Syndrome

Answer 11

vasculitis similar to Wegener granulomatosis

Question 12

Churg-Strauss Syndrome characterized by

Answer 12

chronic lung involvement, neuropathy, skin lesions, GI, cardiac, and renal involvement.

Question 13

All forms of vasculitis are characterized by

Answer 13

fever, weight loss, and a generalized malaise

Question 14

CS is characterized by

Answer 14

a history of asthma, eosinophilia, and other atopic diseases.

Question 15

Diagnosis of CS requires

Answer 15

elevated eosinophils and positive P-ANCA.

Question 16

The most accurate test of CS is

Answer 16

lung biopsy showing the granulomas and eosinophils.

Question 17

Treatment is

Answer 17

cyclophosphamide and glucocorticoids.

Question 18

define Goodpasture Syndrome

Answer 18

idiopathic disorder of renal and lung disease characterized by a unique antibasement membrane antibody.