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SYMAPTHOMIMETICS DRUG Flashcards

(55 cards)

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1
Q

ENDOGENOUS AGONIST ARE:

A

ADRENALINE
NORADRENALINE
DOPAMINE

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2
Q

a1 IS A Gs/Gq/Gi

A

Gq

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3
Q

B1 IS A Gs/Gq/Gi

A

Gs

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4
Q

a2 IS A Gs/Gq/Gi

A

Gi

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5
Q

D IS A Gs/Gq/Gi

A

Gs

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6
Q

B2 IS A Gs/Gq/Gi

A

Gs

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7
Q

WHERE DOES a1 ACT ON AND WHAT IS THE EFFECT?

A

VASCULAR SMOOTH MUSCLE- VASOCONSTRICTION
HEART- + INOTROPIC EFFECT
PROSTATE- CONTRACTION
PUPILLARY DILATED MUSCLES- CONTRACTION (PUPIL DILATATION)

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8
Q

WHRE DOES a2 ACT ON AND WHAT IS THE EFFECT OF a2?

A

PRESYNAPTIC MEMBRANE OF ADRENERGIC AND CHOLINERGIC NERVE - INHIBITION OF THE TRANSMITTER RELEASE
PLATELETS- AGGREGATION

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9
Q

WHERE DOES B1 ACT ON AND WHAT IS THE EFFECT OF B1? (MNEMONICS: BHK1)

A

HEART- POSITIVE EFFECT
KIDNEY (JUXTAGLOMERULAR CELLS) - RENIN SECRETION

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10
Q

WHERE DOES B2 ACT ON AND WHAT IS THE EFFECT OF B3? (MNEMONICS: BML2)

A

RESPIRATORY, VASCULAR AND UTERINE SMOOTH MUSCLE - RELAXATION
PANCREAS - INSULIN SECRETION

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11
Q

WHERE DOES D1 AND D2 CAN BE FOUND?

A

D1 - KIDNEY VASCULAR SMOOTH
D2 -NERVE ENDINGS

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12
Q

STATE THE DIRECT ACTING SYMPATHOMIMETICS DRUGS NON SELECTIVELY.

A

A1A2B1B2- ADRENALINE
A1A2B1- NORADRENALINE
D1D2B1- DOPAMINE
B1B2- ISOPROTERENOL

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13
Q

SELECTIVE DIRECT ACTING SYMPATHOMIMETICS DRUG

A

A1- PHENYLEPHRINE
A2- CLONIDINE
B1- DOBUTAMINE
B2- SALBUTAMOL

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14
Q

ADRENALINE IS AN ___ CATECHOLAMINE: HORMONE/ ___/ ___

A

ADRENALINE IS AN ENDOGENOUS CATECHOLAMINE: HORMONE/ NT/ MEDICATION

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15
Q

ADRENALINE IS GIVEN VIA

A

PARENTERAL ROUTE, IN AN EMERGENCY SITUATION, IT WAS GIVEN VIA IV.

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16
Q

ADRENALINE IS HYDROPHOBIC/ HYDROPHILIC.

A

HYDROPHILIC

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17
Q

ADRENALINE IS RAPIDLY INACTIVATED BY

A

COMT AND MAO

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18
Q

STATE THE EFFECTS OF ADRENALINE.

A
  1. REDISTRIBUTION OF BF
    - REDUCES THE CUTANEOUS BF (VASOCONSTRICTION)
    - INCREASES THE MYOCARDIAL AND SKELETAL MUSCLE BF
  2. HEART POSITVE
  3. BRONCHIAL DILATION
  4. REDUCES MUCOSAL SECRETION/ CONGESTION
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19
Q

ADRENALINE IS GIVEN IV DURING

A
  • CARDIAC ARREST
  • ANAPHYLACTIC SHOCK
  • SEVERE ACUTE ASTMA (STATUS ASTMATICUS)
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20
Q

ADRENALINE IS GIVEN TOPICALLY DURING

A

PROLONG ACTION OF LOCAL ANESTHETICS DUE TO LOCAL VASOCONSTRICTION

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21
Q

NORADRENALINE IS GIVEN VIA

A

IV IN DISTRIBUTIVE/ VASODILATORY SHOCK SUCH AS IN ANAPHYLACTIC/ SEPTIC SHOCK

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22
Q

NORADRENALINE’S EFFECT

A

VASOCONSTRICTION
OTHER SYMPATHETIC EFFECT

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23
Q

NORADRENALINE IS SECRETED BY

Study These Flashcards
A

ADRENAL MEDULLA AND THE SYMPATHETIC NERVE TERMINALIS

24
Q

DOPAMINE IS THE PRECURSOR FOR

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A

ADRENALINE AND NA

25
DOPAMINE IS GIVEN VIA
IV
26
DOPAMINE IS A DOSE DEPENDENT EFFECT IN WHICH - LOW CONCENTRATION- STIMULATE ___ - MODERATE CONCENTRATION - STIMULATE ___ - HIGH CONCENTRATION - STIMULATE ___
DOPAMINE IS A DOSE DEPENDENT EFFECT IN WHICH - LOW CONCENTRATION- STIMULATE D1 AND D2 - MODERATE CONCENTRATION - STIMULATE B1 - HIGH CONCENTRATION - STIMULATE A1
27
CLINICAL USE OF DOPAMINE
- SHOCK (CARDIOGENIC SHOCK) - CHF (INCREASE CO) - RENAL INSUFFICIENCY ( INCREASE RENAL FILTRATION AND CAUSE DIURETIC EFFECT)
28
EFFECT OF PHENYLEPHRINE`
ARTERIAL VASOCONSTRICTION -> INCREASE BP MUCOSAL DECONGESTION MYDRIASIS
29
PHENYLEPHRINE IS GIVEN VIA
TOPICAL (INTRANASAL) IV ROUTE
30
CLINICAL USE OF PHENYLEPHRINE
NASAL DECONGESTANT (T(X) OF RHINITIS)
31
STATE THE DRUG OF A2 SELECTIVE AND ITS EFFECT.
A2 SELECTIVE - CLONIDINE EFFECT 1. REDUCES BP 2. BRADYCARDIA
32
STATE HOW DOES A2 WORKS
1. PREVENT THE RELEASE OF NA -> REDUCES THE SYMPATHETIC OUTFLOW 2. ACTIVATE THE PARASYMPATHETIC REGULATION OF CVS
33
STATE HOW CLONIDINE IS BEING ADMINISTERED
ORAL
34
CLINICAL USE OF CLONIDINE
HPT
35
STATE THE DRUG OF B1 SELECTIVE.
DOBUTAMINE
36
STATE THE EFFECT OF DOBUTAMINE
POSITIVE HEART EFFECTS
37
HOW DOES DOBUTAMINE ADMINISTERED
IV
38
DOBUTAMINE IS USE IN
CHF
39
STATE THE NAME OF DRUG FOR B2 SELECTIVE AND ITS EFFECT
B2 SELECTIVE- SALBUTAMOL EFFECT 1. SMOOTH MUSCLE DILATION - BRONCHIAL DILATION - VASODILATION - UTERINE MUSCLE DILATION
40
THE ROUTE OF ADMINISTRATION FOR SALBUTAMOL
INHALATION ORAL IV
41
CLINICAL USE OF SALBUTAMOL
BRONCHIAL ASTHMA T(X) OF PRETERM LABOUR
42
B2 SELECTIVE ADR
REFLEX TACHYCARDIA
43
ADR OF PHENYLEPHRINE
DEVELOP TOLERANCE REBOUND CONGESTION CNS STIMULATION
44
STATE THE INDIRECT ACTING SYMPATHOMIMETICS DRUG: - RELEASING AGENT - UPTAKE INHIBITOR - MAO/ COMT INHIBITOR
- RELEASING AGENT- AMPHETAMINE - UPTAKE INHIBITOR- AMITRIPTYLINE, COCAINE - MAO/ COMT INHIBITOR- SELEGILINE
45
DESC AMPHETAMINE
AMPHETAMINE IS A RELEASING AGENT IT WILL STIMULATE THE RELEASE OF CATECHOLAMINES WHICH ARE NA AND ADRENALINE FROM THEIR VESICLES IN NERVE TERMINALS IT WILL CAUSE INCREASE IN BP AND MYOCARDIAL STIMULATION IT WILL ALSO CAUSE EUPHPRIA, EXCITATION, AND DELIRIUM AMPHETAMINE IS USE IN ADHD PT AS WELL LOA (APPETITE SUPPRESSANT)
46
MOA OF AMITRIPTYLINE
BLOCK THE UPTAKE OF NA FROM THE SYNAPSE BACK TO THE NERVE TERMINAL IN CNS -> MORE NA PRESENT IN SYNAPSE AND INTERACT WITH RECEPTOS
47
EFFECTS OF UPTAKE INHIBITOR DRUG
UPTAKE INHIBITOR - AMITRIPTYLINE EFFECT: - IMPROVE MOOD - TACHYCARDIA - ARRHYTHMIAS
48
49
CLINICAL USE OF UPTAKE INHIBITORS
DEPRESSION
50
MAO INHIBITORS
- METABOLISE CATECHOLAMINE (ADR, NA, DOPAMINE) AND SEROTONIN - PRESENT INTRACELLULARLY - PRESENT IN THE CNS ONLY - HAS 2 ISOFORMS 1. MAO-A: PREFERENCE TO NA, SEROTONIN, ADR 2. MAO-B: PREFERENCE TO DOPAMINE
51
COMT INHIBITORS
- METABOLISE CATECHOLAMINES - PRESENT EXTRACELLULARLY - PRESENT IN THE CNS AND PERIPHERAL TISSUES
52
PHENELZINE
A NON SELECTIVE MAO- AND B INHIBITORS IT PREVENT DEGRADATION OF CATECHOLAMINES IN NERVE TERMINALS IT IS USE IN DEPRESSION
53
SELEGILINE
A SELECTIVE MAO- B INHIBITORS IT PREVENT DEGARADATION MAINLY THE DOPAMINE IN NERVE TERMINALIS IT IS USE IN PARKINSON DISEASE
54
TOLCAPONE
A COMT INHIBIT AND PREVENT DEGRADATION OF LEVODOPA (ANTIPARKINSON DRUG), PERIPHERALLY AND DOPAMINE (CENTRALLY) IT IS USE TO TREAT PARKINSON DISEASE
55
EPHEDRINE
A NONSELECTIVE AGONIST A1A2B1B2 INCREASE THE NA RELEASE ORAL ROUTE EFFECT: INCREASE TPR, POSITIVE HEART EFFECT, BRONCHIAL DILATION AND CNS STIMULATION

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