Sympathomimetics Flashcards Preview

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Flashcards in Sympathomimetics Deck (16):
0

Epinephrine receptor sensitivity and application

Sympathomimetic.
B1 = B2 > alpha1=alpha2. No D1.
Trts anaphylaxis, glaucoma (open angle), asthma and hypotension.

1

Norepinephrine receptor sensitivity and application

Sympathomimetic.
Alpha1=alpha2 >>beta 1. No beta 2 or D1
Hypotension but decreases renal perfusion!

2

Isoproterenol receptor sensitivity and application

Sympathomimetic.
Beta1=beta2 only
Rare: AV BLOCK

3

Dopamine receptor sensitivity and application

Sympathomimetic.
Low dose: D1
Medium dose: beta1&2
High dose: alpha1&2
Treats shock (renal perfusion), HF, inotropic and chronotropic; D1>beta>alpha.

4

Dobutamine receptor sensitivity and application

Sympathomimetic.
Beta1>>> beta2=alpha1&2
Treats HF, used for cardiac stress testing. Inotropic and chronotropic.

5

Phenylephrine receptor sensitivity and application

Sympathomimetic.
Alpha 1>>> alpha 2
Used to dilate pupils, vasoconstriction, and nasal decongestion.

6

Ritodrine uses and action

Beta2 agonist which reduces premature uterine contractions.

7

Metaproterenol receptor sensitivity and application

Sympathomimetic
Beta2>>>beta1
Treats acute asthma.

8

Albuterol receptor sensitivity and application

Sympathomimetic.
Beta2>>beta1
Treats acute asthma

9

Salmeterol receptor sensitivity and application

Sympathomimetic
Beta2>>>beta1
Long term treatment of asthma

10

Terbutaline receptor sensitivity and application

Sympathomimetic.
Beta2>>>beta1
Reduces premature uterine contractions

11

Amphetamine method of action and application

Indirect Sympathomimetic.
Indirect general agonist, releases catecholamine stores.

Treats narcolepsy, obesity, & ADD

12

Ephedrine method of action and application

Indirect Sympathomimetic
Indirect general agonist, releases stored catecholamine.
Treats nasal decongestion, urinary incontinence, & hypotension

13

Cocaine method of action and application

Indirect Sympathomimetic
Indirect general agonist, uptake inhibitor
Causes vasoconstriction and local anesthesia.

14

Clonidine mechanism of action and uses

Sympathoplegic: inhibits postganglionic SNS.
stimulates alpha-adrenoreceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and in decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
Treats hypertension while increasing renal flow

15

alpha-methyldopa mechanism of action and uses.

Sympathoplegic: inhibits postganglionic SNS.
stimulates alpha-adrenoreceptors in the brain stem. This action results in reduced sympathetic outflow from the central nervous system and in decreases in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.
Treats hypertension while increasing renal flow