Symptoms in the Pharmacy - Women’s Health Flashcards

(75 cards)

1
Q

overview of women’s health:

A

Cystitis
Vaginal thrush
Dysmenorrhoea
Menorrhagia
Emergency hormonal contraception
Progestogen only contraception
Menopause and perimenopause

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2
Q

Why explain why you are asking questions about health in detail to patients?

A

can be private and sensitive

take patient into private area

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3
Q

What is Cystitis?

A

Upper Urinary Tract Infection (UTI)
- Pyelonephritis
Infection/inflammation of kidney(s)
Ureteritis
Infection/inflammation of ureter(s)

Lower Urinary Tract Infection (UTI)
- Cystitis
Infection/ inflammation of bladder
Urethritis
Infection/inflammation of urethra

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4
Q

When does Cystitis occur?

A

when bacteria pass up along urethra and enter and multiply within the bladder, causing inflammation

50% cases- no cause identified

caused in GI tract = E.coli

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5
Q

Cystitis - common in females, why?

A

wrethra is longer in women

more coplex if UTI is found in make

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6
Q

How long does cystitis last?

A

Majority of cases are self-limiting and resolve in around 3 days

OTC management if symptoms are mild, or to help until patient can see GP

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7
Q

Cystitis- Causes

A

Wiping back to front, exposing urethra to faecal bacteria
Previous infection not fully clearing
Diabetes- sugary environment for bacteria to thrive
‘Honeymoon cystitis’- sexual intercourse causing minor trauma or pushing bacteria along urethra
Irritant effects of toiletries- bubble baths & vaginal deodorants
Irritant effects of chemicals- spermicides and disinfectants
Post-menopausal changes to vaginal lining thins and less lubrication therefore more prone to trauma/irritation > cystitis
Some medication- cyclophosphamide + methenamine (no evidence to suggest that contraceptive pill increases risk)

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8
Q

Normal symptoms of cystitis:

A

Signs of impending attack: itching or pricking sensation in urethra
More frequent desire to pass urine
Urgent need to pass urine throughout day and night
Can only pass few burning, painful drops of urine (dysuria)
Bladder may not feel completely empty after urinating
Cloudy and strong-smelling urine: sign of bacterial infection

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9
Q

Symptoms Needing Referral Cystitis

A

Haematuria (blood in urine)- may just be severe UTI, but could be kidney stone (blood with pain) or potentially bladder/kidney cancer (blood but no pain)
Symptoms suggestive of upper UTI- pain in lower back, loin pain and tenderness, systemic symptoms such as fever, nausea and vomiting
Abnormal vaginal discharge- local fungal or bacterial infection
Cystitis symptoms & alteration in vaginal discharge & lower abdo pain= ? chlamydia

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10
Q

Cystitis – Self-management (& preventing recurrence)

A

1) Avoiding irritants
No need to clean vagina with douches or deodorants- it self-cleans

2) Drink plenty of water
Traditional advice to drinks loads to encourage urination to flush out the bacteria, but this will cause discomfort. Best to drink normally to ensure hydration

3) Empty bladder fully
Wait 20 seconds after passing urine then strain to empty final drops. Leaning back may help, rather than the usual sitting posture

4) Wipe front to back after a bowel motion

5) Urinate after sexual intercourse

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11
Q

cranberry juice?

A

do not recommend unless patient is adamant to try it - can interact with other drugs (statins’)

symptomatic relief

no evidence it can CURE cystitis

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12
Q

Cystitis- OTC Management for pain relief and alkalising products.

A

Pain Relief:
Paracetamol and/or ibuprofen for up to 2 days
Help with dysuria and any discomfort felt

Alkalising Products:
Potassium citrate or sodium citrate
Idea is that they make urine more alkaline to help with dysuria
Will cause symptomatic relief but not treat the cause (infection)

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13
Q

Alkalising Agents;

A

Potassium citrate
Sodium citrate

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14
Q

Sodium citrate

A

Only take stated dose of product

Contraindicated in patients with hypertension, heart disease or are pregnant

Available as granules

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15
Q

Potassium citrate

A

Only to take stated dose of product- some cases of severe hyperkalaemia reported

Contraindicated in patients taking medication which may also cause hyperkalaemia

Potassium-sparing diuretics (e.g. spironolactone), ACE inhibitors

Available as potassium citrate mixture- unpleasant taste, so dilute well with cold water
Available as potassium citrate granules

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16
Q

What are the antibiotic options to treat cystitis?

A

can test for UTI in pharmacies

Only able to treat uncomplicated UTIs in women aged 16-65 years = dipstick +ive - offer treatment

Trimethoprim or Nitrofurantoin

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17
Q

Trimethoprim or Nitrofurantoin how long to take it for?

A

3 days

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18
Q

Cystitis- Who to Refer to GP?

A

Children
Males
Pregnant females
Post-menopausal women- could be vaginal atrophy
Catheterised patients
Upper UTI symptoms
Symptoms of systemic infection- fever/nausea/vomiting
Haematuria or abnormal vaginal discharge
Symptoms lasting longer than 2 days
Recurrent cystitis- could be diabetes
Failed treatment

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19
Q

What causes vaginal thrush?

A

Common yeast infection
Candida albicans
Not an STI
If infected, partner might need treatment too

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20
Q

Vaginal Candidiasis- Symptoms?

A

Itch (pruritis) around the vagina
Intense and burning in nature
Skin may be excoriated and raw from scratching if severe

Check this is not due to using any new toiletries- could be dermatitis not thrush
Vaginal discharge

Normal= thin and watery, no smell
Candidiasis= white/cream-coloured, thick like cottage cheese, sometimes an unpleasant smell but not always

Bacterial infection= yellow/green-coloured, strong foul odour
Vaginal soreness

Dysuria (pain on urination)

Dyspareunia (painful sexual intercourse)

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21
Q

Vaginal Candidiasis- Risk Factors

A

yeast = grows in warm/moist conditions and develops the balance of vaginal bacteria changes

age = common in women of childbearing age (low pH and presence of glycogen)

recent consumption a course of antibiotics

pregnancy

diabetes

weakened immune system

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22
Q

Prevention of vaginal thrush:

A

Dry area properly after washing

Avoid tight/nylon tights or underwear

Avoid perfumed soaps and shower gels

Wipe front to back after bowel motions

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23
Q

Vaginal Candidiasis- Management
Manged with azole antifungals:

A
  1. Topical vaginal cream
  2. Pessary
  3. Oral capsule
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24
Q

Can OTC products be given for vaginal thrush?

A

yes - mixture of formulations

Offer treatment for free Via Common ailment Scheme

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25
Management- Topical vaginal cream EXTERNAL cream
Clotrimazole 2% cream (Canesten®) - immediate symptomatic relief of itch - apply thinly to VULVA and surrounding area BD-TDS until symptoms disappear
26
Side effects of topical vaginal cream EXTERNAL
Itching/burning sensation can damage latex contraceptives - use alternative precautions for at least 5 days after using product
27
Management- Topical vaginal cream INTERNAL cream
Clotrimazole 10% cream (Canesten®) Administer intravaginally using the applicator supplied One-off treatment, best administered at night
28
side effects of Topical vaginal cream INTERNAL
Itching/burning sensation Uncomfortable (formulation) damage latex contraceptives- use alternative precautions for at least 5 days after using product Not to be used during periods- may wash out
29
Management- Pessary
Clotrimazole 500mg, 200mg or 100mg (Canesten®)
30
How to apply pessary?
Administer intravaginally as high as possible using the applicator supplied
31
Different dosage of pessaries:
500mg pessary: One-off treatment at night, can be repeated in 7 days if infection returns (only this is available via Common Ailments Scheme) 200mg pessary: One pessary daily at night for 3 days 100mg pessary: Two pessaries daily at night for 3 days OR one pessary daily at night for 6 days
32
Side effects of pessary
Itching/burning sensation Uncomfortable If using longer course = need motivation Not to be used during periods- may wash out Do not use tampons/intravaginal douches/spermicides etc during treatment
33
Management- Oral capsule
Fluconazole 150mg oral capsule (Canesten®) One-off dose, to be swallowed whole May take 12-24 hours for symptoms to improve
34
What are the Key drug interactions for oral Capsule:
warfarin, statins, phenytoin, rifampicin, ciclosporin and theophylline Single dose may not affect drug levels too much, but will need to refer to GP
35
Side effects of oral capsule e.g. Fluconazole
mild and transient; include nausea, abdo discomfort, flatulence and diarrhoea. Convenient and acceptable formulation
36
Candidiasis symptoms in males (candidal balanitis)
Male may catch infection from a female partner May be asymptomatic
37
Symptoms of Candidiasis in MALES;
Irritation, burning and redness around the head of the penis and under the foreskin White/cream-coloured discharge, thick in consistency like cottage cheese Discharge which may or may not have an unpleasant smell Difficulty pulling back the foreskin
38
What is the Management for Candidiasis in males?
Azole external cream BD for 6 days or oral fluconazole STAT
39
Candidiasis- When to refer to GP
First occurrence of symptoms- to confirm diagnosis Allergic to antifungals Pregnant or breast feeding Immunocompromised More than 2 thrush attacks in previous 6 months Previous exposure to STI or partner with STI Women aged under 16 or over 60 Abnormal/irregular vaginal bleeding Blood-stained vaginal discharge // Foul smelling discharge Vulval or vaginal sores/blisters/ulcers Associated lower abdo pain or dysuria Adverse effects related to treatment (redness/irritation/swelling) No improvement within 7 days of treatment OTC licensing of candidiasis products reflect these referral criteria
40
Dysmenorrhoea
period pains
41
Primary Dysmenorrhoea
Pain without underlying causes Manage in community pharmacy 1 in 2 women suffer, while 1 in 10 have severe symptoms, requiring time off work or school Peak incidence: 17-25 years of age
42
Secondary Dysmenorrhoea
Pain with underlying disease, e.g. endometriosis or pelvic inflammatory disease
43
Primary Dysmenorrhoea DETAILED
- cramping lower ab pain - begins before start bleed - pain eases after menstruation - gone by end of first day of bleeding - Not associated with the start of menstruation (menarche) because ovulation doesn’t happen within the first few months/years of menstruation [ Women often state that period pain begins several months/years after pain-free menstruation [Women often state that period pain begins several months/years after pain-free menstruation]
44
Dysmenorrhoea is different to mittelschmerz
Mittelschmerz = ovulation pain. This pain is mid-cycle at the time of ovulation. It usually lasts a few hours, some report some bleeding too Therefore important to identify timing of pain to differentiate
45
Primary Dysmenorrhoea- Management Non-drug management:
Exercise (endorphins help) TENS machine (alters ability to receive/perceive pain signals) Acupuncture Locally applied low-level heat (heat pads or even warm bath) Supplements like fish oil or vitamin B- evidence is patchy
46
Primary Dysmenorrhoea- Management Drug management:
Simple analgesia (NSAIDs best) Hyoscine butylbromide (antispasmodic)– evidence is patchy Caffeine (enhance analgesic effect)
47
Dysmenorrhoea- NSAIDs
Pain of dysmenorrhoea linked to increased prostaglandin activity NSAIDs block synthesis of prostaglandins, which is why they are effective in treating period pains
48
Treatment for Dysmenorrhoea
Ibuprofen: 200-400mg TDS with food Naproxen: 500mg initially then 250mg 6-8 hours later if needed. Max 3 days treatment can be supplied OTC. NSAIDs not appropriate if allergy (incl. aspirin), asthma or GI bleeds. Could offer these patients paracetamol- doesn’t work on prostaglandins but may have some benefit Take painkillers regularly for 2-3 days each period, not just PRN
49
What is Menorrhagia?
Heavy menstrual bleeding Excessive blood loss interferes with a woman’s physical, social, emotional and material quality of life
50
what is the average menstrual blood loss for a woman compared to Menorrhagia
30-40mL per cycle Menorrhagia: 60-80mL or more per cycle
51
Only OTC product to treat/ manage Menorrhagia is:
Tranexamic acid
52
Menorrhagia- Tranexamic acid is a type of what drug
antifibrinolytic Inhibits fibrinolysis > increased clot formation > reduced blood loss
53
How to administer Tranexamic acid for Menorrhagia
Only take once heavy bleeding has started (not before) Two x 500mg tablets TDS until symptoms alleviated, for a maximum of 4 days OTC If bleeding very heavily, can increased to a maximum of eight tablets a day (4g daily) Can repeat for each menstrual cycle
54
Menorrhagia- When to Refer to GP
Women under 18 or over 45 years of age Tried tranexamic acid for three menstrual cycles without a reduction in bleeding Breastfeeding women Obese or diabetic patients (could be PCOS) If tranexamic acid contraindicated or cautioned- e.g. in history of convulsions, taking warfarin, taking oral contraceptives Signs of iron-deficient anaemia: tiredness, paleness Irregular bleeding/abnormal bleeding/bleeding between periods/prolonged periods – may be endometrial cancer Bleeding between periods/pain during sex/ bleeding after sex/ bleeding after menopause – may be cervical cancer History of clotting- e.g. PE, DVT
55
Are Oral Contraception POM?
majority
56
Example of oral contraception:
P med: desogestrel 75mg tablets (Lovima® and Hana®) Type of progesterone-only pill (POP) Can be 99% effective in preventing pregnancy Must only sell: As a form of contraception (i.e. no other indication) To women of childbearing age (under 18s to be supplied based on clinical judgement as no info on safety or efficacy in SPC) Dose: 1 tablet daily (no break between packs)
57
Contraindications - oral contraception
Blood clots, cancer, soya/peanut allergy (Lovima® contains soya bean oil, so avoid in both allergy types)
58
Interactions - oral contraception
Refer anyone with clinically relevant interaction (e.g. antiepileptics)
59
When do you take oral contraception?
Take on Day 1 of period, otherwise will need additional barrier contraception if starting on days 2-5. RPS has guidance on when to start in other situation, e.g. after EHC, after childbirth, after miscarriage, if switching between contraceptives
60
What if oral contraception pills are missed?
Under 12 hours: Take ASAP and continue as normal Over 12 hours: Protection lost, take ASAP and use barrier methods for 7 days. May need EHC.
61
side effects of oral contraception?
Common: irregular periods, altered mood, headaches, nausea, weight changes If vomits within 3-4 hours, follow missed pill rules
62
supplies of oral contraception
First supply- up to 3 months can be supplied Repeat supply- up to 12 months can be supplied Women under 18- up to 3 months can be supplied Only OK to supply if: Not pregnant No bleeding between period/after sex No health conditions No allergies Not taking other meds otherwise, refer
63
Emergency Hormonal Contraception - morning after pill
2 products licensed OTC: Levonorgestrel 1500 microgram tablet (Levonelle®) Ulipristal acetate 30mg tablet (Ella One®) Next period may be sooner, later or on time. If lighter, shorter or 3 days later than usual, need to take pregnancy test.
64
how old to sell OTC emergency contraceptive?
16+ Some areas have PGDs where it can be supplied for free under locally agreed protocol (usually from 13 years)
65
EHC- What do you need to know to supply safely?
what happened? - failure of barrier contraceptive (condom splits) - missed contraceptive pill -unprotected sex when> - explain why asking - EHC most effective the sooner its taken after unprotected sex - answer will influence already pregnant? - last period normal/lughter/later? - Any other episodes of unprotected sex during this cycle?
66
EHC- Other points to consider
Supply to a patient representative Moral beliefs Advance supply of EHC Long-term contraception and sexual health
67
EHC- Other points to consider Vulnerable adults and children
Cannot sell to under 16s, but they may fall under local PGD Should be aware of issues such as non-consensual intercourse, child protection issues, vulnerable adults, consent and confidentiality RPS and Dept of Health have guides with practical advice on managing vulnerable adults, e.g. if domestic violence suspected Children under 13 are deemed too young to consent, so cases should be reported to social services Sexual activity with children under 16 is an offence, but may be consensual. Law will not prosecute mutually agreed sex between young people of a similar age, unless it’s abuse or exploitation Can provide contraception and sexual health advice to children under 16 and patient confidentiality applies- do not need parent consent. Should obtain consent to share information; this does not apply if it’s in the child’s best interest to share (e.g. to prevent harm or to protect the child). Can seek advice from experts without disclosing identifiable details, however.
68
Menapause different types
Perimenopause Menopause
69
Perimenopause
Woman has irregular cycles of ovulation and menstruation leading up to menopause, continues for 12 months after final period
70
Menopause
Biological state having occurred when a woman has not had her period for 12 consecutive months. The ovaries stop maturing eggs and secreting oestrogen + progesterone, menstruation stops and she can no longer conceive
71
Menopause- Symptoms
Vasomotor symptoms: hot flushes, sweats Musculoskeletal symptoms: joint and muscle pain Urogenital symptoms: vaginal dryness, urinary frequency, UTIs Other symptoms: low mood, reduced libido
72
Menopause- Self-management
Hot flushes & night sweats Keeping cool- light clothing, cool showers, using fans Keep bedroom cool at night Avoid triggers- caffeine, spicy food, smoking, alcohol Exercise & lose weight if overweight Mood changes Plenty of rest, take exercise, relaxing activities such as yoga Weak bones (> oestrogen = > risk osteoporosis) Regular weight-bearing and resistance exercise, healthy diet with sources of calcium, getting some sunlight Stop smoking, less alcohol & calcium/vit D supplements
73
Menopause- OTC Management
Vasomotor symptoms Black cohosh Isoflavones St John’s Wort used for depression) Urogenital Symptoms Vaginal dryness- OTC vaginal moisturisers and lubricants (Vagisil®,Vagisan®)
74
NICE advice on herbal medicines in menopause
Despite NICE guidelines suggesting black cohosh or isoflavones may help with vasomotor symptoms, they state that the following should be explained: Some evidence for it, but not robust Multiple preparations are available and their safety is uncertain Different preparations may vary Interactions with other medicines have been reported
75
Menopause – When to refer to GP?
Contraindications to treatment Experienced side effects Symptoms don’t sound like vaginal atrophy Hx of endometriosis Already on systemic HRT / using a different local HRT Anyone who doesn’t fit selling criteria (e.g. women under 50, last period was less than 1 year ago etc) If symptoms worsen/don’t improve after 7 weeks Tx Red flag symptoms: Vaginal – undiagnosed bleeding, smelly/unusual discharge, severe itching Vulva – changes to look/texture/colour, soreness, rashes, lumps, swelling Pain – pelvic, when passing urine Lower abdominal – pain, bloating, swelling