Synaptic Transmission

Question 1

Most of the synapses in the body are

Answer 1

chemical synapses

Question 2

where are NTs stored?

Answer 2

presynaptic vesicles

Question 3

narrow space that separates the pre and postsynaptic cell

Answer 3

synaptic cleft

Question 4

contains the postsynaptic receptors

Answer 4

postsynaptic densities

Question 5

excitation-secretion coupling phase time

Answer 5

less than 1 ms

Question 6

recovery phase time

Answer 6

less than 1 second

Question 7

recycling phase time

Answer 7

less than 1 min

Question 8

excitation-secretion coupling phase deals with

Answer 8

the Ca influx/exocytosis thing

Question 9

recovery phase: presynaptic Ca channels close following

Answer 9

membrane hyperpolarization

Question 10

recycling phase: synaptic vesicles which underwent exocytosis are ( )

Answer 10

endocytosed

Question 11

synaptic vesicles are docked at the presynaptic terminal membrane via formation of the ( )

Answer 11

SNARE protein complex

Question 12

Structure of SNARE complex

Answer 12

1) syntaxin
2) synaptobrevin
3) SNAP-25

Question 13

botulism and tetanus are caused bye

Answer 13

clostridial toxins

Question 14

Examples of Amines

Answer 14

• Ach
• Histamine
• Serotonin

Question 15

Examples of Catecholamines

Answer 15

• Dopamine
• Epinepherine
• Norepinepherine

Question 16

Examples of Amino Acids

Answer 16

• Aspartic acid
• GABA
• Glutiamic acid
• Glycine

Question 17

Exmaples of Polypeptides

Answer 17

• Glucagon
• Insulin
• Somatostatin
• Angiotension II

Question 18

Examples of Lipids

Answer 18

Endocannabinoids

Question 19

Examples of Gases

Answer 19

-Nitric oxide

0Carbon monoxide

Question 20

Major excitatory NT

Answer 20

glutamate

Question 21

Major inhibitory NT

Answer 21

GABA

Question 22

At the NMJ the most common NT is

Answer 22

Ach

Question 23

nicotinic receptor

Answer 23

ionotropic (liagand gated)

Question 24

muscarinic receptor

Answer 24

metabotropic (G-coupled)

Question 25

Summation of incoming signals in space and time

Answer 25

synaptic integration

Question 26

lethal toxin: interfere with synaptic vesicle docking or fusion process

Answer 26

clostridium neurotoxins

Question 27

lethal toxin: blocks AchR

Answer 27

alpha-bungarotoxin

Question 28

lethal toxin: blocks acetylcholinesterase

Answer 28

nerve gas

Question 29

lethal toxin: blocks presynaptic Ca2+ channels

Answer 29

w-conotoxin

Question 30

drugs: monoamine reuptake inhibitor

Answer 30

cocaine

Question 31

drugs: serotonin reuptake inhibitor

Answer 31

anti-depressants (Prozac)

Question 32

drugs: stimulate IPSP by acting on opioid receptors linked to K channel activation

Answer 32

opioids (morphine)

Question 33

drugs: presynaptic calcium channel blocker in clinical trials as pain-killer

Answer 33

SNX-111 (synthetic analog of w-conotoxin)