synaptic transmission and nt receptors

Question 1

Ionotropic receptors

Answer 1

Form ion channels that depolarise or hyperpolarise the post-synaptic cell
Multi-subunit
Fast responses
e.g. AMPA/kainate/NMDA

Question 2

Metabotropic receptors

Answer 2

Couples to intracellular proteins that transduce the signal to the cell interior
Monomeric (or dimers)
Slow responses
e.g. mGluR1-mGluR8

Question 3

Current

Answer 3

Ion flow

Same direction as positive ions

Question 4

EPSP

Answer 4

Makes neurone more likely to fire an AP

Question 5

IPSP

Answer 5

Makes neurone less likely to fire AP

Question 6

syntaptobrevin

Answer 6

vesicle bound protein which binds SNAP-25 on the plasma membrane
vesicle docking/priming

Question 7

synaptotagmin

Answer 7

calcium ion sensor

fusion

Question 8

axo-dendritic synaptic connection

Answer 8

can occur on the dendritic spines or directly on the dendritic shaft
common on dendrites of principal cells of most brain regions
commonly excitatory

Question 9

oxo-somatic synaptic connection

Answer 9

synapses of cell bodies are often inhibitory e.g. GABAergic

synapses on initial segment of axon will influence all firing greatly

Question 10

axo-axonic

Answer 10

modulator - control nt release
can increase or decrease nt release
control the calcium influx in presynaptic neuron

Question 11

neuronal integration

Answer 11

summation of all the EPSPs and IPSPs

occurs at the axon hillock/initial segment

Question 12

temporal summation

Answer 12

summation of PSPs occurring over short periods of time

Question 13

spatial summation

Answer 13

summation of PSPs over membrane surface

Question 14

myelin

Answer 14

insulating layer wrapped around axon membrane which prevents current leakage
produced by oligodendrocytes (CNS) and Schwann cells (PNS)