Syndrome of Inappropriate ADH (SIADH) Flashcards
1
Q
Pathophysiology of SIADH and consequential blood test results?
A
Inappropriate ADH thus too much water is reabsorbed
- serum Na decreased
- urine osmolality increased
- urine Na increased
2
Q
Presentation of SIADH?
A
Symptoms and signs of hyponatraemia
3
Q
Causes of SIADH?
A
CNS pathology
Lung pathology (pneumonia)
Drugs (SSRIs, TCA, opiates, PPIs, carbamazepine)
Tumours (breast cancer as well)
4
Q
Signs of SIADH?
A
Low serum Sodium
Urine osmolality high
Urine Sodium high
5
Q
Management of SIADH?
A
1 - Treat the underlying cause
2 - Fluid restriction to 0.5-1L
3 - If ineffective, give demeclocycline or vasopressin receptor antagonist (tolvaptan)
6
Q
Risk factors for SIADH?
A
(basically just the causes)
>50 years
Pulmonary conditions
Malignancy
