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LAB MEDCHEM ORG CHEM > synthesis of acetylsalicylic acid > Flashcards

synthesis of acetylsalicylic acid Flashcards

1
Q

Active extract

A

(willow bark)

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2
Q

scientific name of white willow

A

(Salix alba)

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3
Q

Latin name of Salicylic acid

A

salicin

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4
Q

ortho to the carboxyl group

A

C6H4(OH)COOH - OH group

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5
Q

salicylic acid also known as

A

2-hydroxybenzoic acid

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6
Q

solubility in water

A

Poorly soluble

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7
Q

solubility in ethyl ether, chloroform, benzene, acetone, turpentine oil

A

soluble

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8
Q

PHYSICAL PROPERTIES of salicylic acid

A

White crystalline powder, first bitter taste the sweet

Pungent odor

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9
Q

Melting point of salicylic acid

A

158.6 °C

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10
Q

5 USES of salicylic acid

A

Food additive
Flavoring agent
Synthesis of ASA
Starting material for other pharmaceutical products (esters, amides)
intermediate in the production of agrochemical products (dyes
and colorants, rubber industry)

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11
Q

PHARMACEUTICAL USES:

A

● Keratolytic agent
● Analgesic
● Antipyretics and anti-inflammatory

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12
Q

unbuffered (without chemicals to keep stable) formulations and tend to have greater impact on the skin.

A

Natural salicylic acid

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13
Q

Benefits: of natural salicylic acid

A

does not increase the blood vessels in the skin like some other acids.

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14
Q

Agents require buffering (stabilizing of the acidity pH) using chemical agents in order to stabilize

A

Synthetic acid agents

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15
Q

Common salicylate-containing medicines

A 
bismuth subsalicylate
choline salicylate
diflunisal
magensium salicylate
slasalate
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16
Q

(IUPAC name of salicylic acid)

A

*2-hydroxybenzoic acid

17
Q

(IUPAC name of salicylic acid)

A

2-hydroxybenzoic acid

18
Q

chemical reaction involved in synthesis of salicylic acid

A

Methyl Salicylate + NaOH → Disodium Salicylate + H2SO4 → Salicylic Acid

19
Q

Reaction with Bromine Water:

A

milky white color

20
Q

Reaction with Ferric Chloride Solution:

A

(blue or violet) complexes

21
Q

Reaction with methyl alcohol:

A

Minty smell

22
Q

combination of salicylic acid and methanol

A

methyl salicylate or oil of wintergreen.

AKA: methyl alcohol and wood alcohol

23
Q

when salicylic acid is treated with the bromine water it leads to the formation of

and this reaction is known as

A

2,4,6 – tribromophenol

bromination of salicylic reaction

LAB MEDCHEM ORG CHEM (3 decks)

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