Systemic Anticancer Treatment

Question 1

Antimetabolites inhibit which phase of cell cycle

Answer 1

S phase

Question 2

Antibiotics inhibit which phase of cell cycle?

Answer 2

Part of G1,
S phase
Part of G2

Question 3

Vinca alkaloids inhibit which phase of cell cycle

Answer 3

1st part of mitosis

Question 4

Taxoids inhibits which phase of cell cycle?

Answer 4

Last part of M phase
1st part of G1

Question 5

Alkylating agents inhibit which part of cell cycle

Answer 5

All of the cell cycle

Question 6

What are the 3 subtypes of antimetabolites

Answer 6

Pyrimidine
Purines
Antifolates

Question 7

Give examples of pyrimidine antimetabolites

Answer 7

5 FU
Capecitabine

Question 8

Give 2 examples of antifolates

Answer 8

Methotrexate
Pemetrexed

Question 9

Major antitumor mechanism of 5FU

Answer 9

Inhibition of thymidine synthethase

Question 10

Mechanism of action of Methotrexate

Answer 10

DiHydroFolate Reductase inhibitor

Question 11

Give examples of Purines antimetabolites

Answer 11

6 MP
Thioguanine
Fludarabine
Cladribine

Question 12

6MP & Thioguanine are ised to treat which type of leukemia

Answer 12

ALL

Question 13

Fludarabine is used to treat which type of leukemia

Answer 13

CLL

Question 14

Cladribine is used for tx of which type of leukemia

Answer 14

Hairy cell leukemia

Question 15

Mention types of Anticancer antibiotics

Answer 15

Anthracyclines
• Doxorubicin/adriamycin
• Daunorubicin
• Epirubicin
• Idarubicin
Bleomycin
Actinomycin D/dactinomycin

Question 16

Main toxicities of anthracyclines

Answer 16

Alopecia
Cardiotoxicity

Question 17

Cumulative dose of antibiotics in cancer

Answer 17

500 mg/m2

Question 18

Mechanism of action of antibiotics in cancer

Answer 18

DNA binding
Topoisomerase 2 inhibitor
Free radical formation

Question 19

Mechanism of action of alkylating agents

Answer 19

Transfer of alkyl group from one molecule to another

Question 20

Mention typea of alkylating agents

Answer 20

Classic
Non classic

Question 21

Mention examples of classic alkylating agents

Answer 21

Nitrogen mustards
Aziridines: Thiotepa

Question 22

Mention examples of non classic alkylating agents

Answer 22

Platimums: cisplatin, carboplatin

Question 23

Mention toxicity of alkylating agents

Answer 23

MAN:
Myelosuppression
Alopecia
N&V

Question 24

Menttion examples of Topoisomerase 1 inhibitors

Answer 24

Topotecan
Irinotecan

Question 25

Mention examples of Topoisomerase 2 inhibitors

Answer 25

Intercalating: Doxorubicin Non intercalating: etoposide, tenoposide

Question 26

Mention types of tubulin binding agents

Answer 26

Vinca alkaloids Taxanes

Question 27

Mention examples of vinca alkaloids

Answer 27

Vinblastine Vincristine

Question 28

Mention examples of tanxanes

Answer 28

Paclitaxel Docetaxel

Question 29

Which of the vinca alkaloids is used for testicular cancer

Answer 29

Vinblastine

Question 30

Which of the vinca alkaloids is used for leukemia, lymphoma?

Answer 30

Vincristine

Question 31

Which of the vinca alkaloids is used for breast and lung cancer

Answer 31

Vinorelbine

Question 32

Which of the Taxanes is used for ovarian cancer

Answer 32

Epothilones

Question 33

Which of the Taxanes is used to treat breast and lung cancer

Answer 33

Docetaxel

Question 34

Paclitaxel (Taxanes) is used to treat which cancers

Answer 34

Breast and ovary

Question 35

What is the tubulin binding agent used for treatment of prostate cancer

Answer 35

Estramustine

Question 36

A patient has been diagnosed with cancer, the doctor prescribed Bevacizumab for her, what is the mechanism of action of Bevacizumab? And what are the side effects that can occur due to it?

Answer 36

MOA: anti-VEGF SE: bleeding, VTE, HTN

Question 37

A patient has been diagnosed with cancer, The doctor prescribed Gefitinib because it acts on a mutation in receptors. What is the receptor mutation for which Gefitinib is used? What are the side effects of Gefitinib?

Answer 37

EGFR mutation Side effects: skin toxicity, tx moisturizers

Question 38

Mention one immunotherapy (anti PD1) receptor

Answer 38

Pembrolizumab