Systemic Diseases

Question 1

What is Behcet’s Disease?

Answer 1

A chronic, relapsing, multi-systemic inflammatory disease of unknown aetiology.

Question 2

What is the age onset of Behcet’s Disease?

Answer 2

30s-40s

Question 3

What are the characteristics of Behcet’s Disease?

Answer 3

recurrent aphthous stomatitis
oral ulcers
genital ulcers
uveitis (eye)
mucocutaneous lesions

Question 4

What is the oral manifestation of Behcet’s disease?

Answer 4

erythmatous, slightly raised area evolving into an oval or round ulcer within 2-3 days, with rolled borders and a grayish yellow necrotic base.

erythematous halo surrounds the ulcer.

Question 5

What is Systemic Lupus Erythmatous?

SLE

Answer 5

A chronic inflammatory autoimmune disease with a highly variable course,
characterised by the production of a wide profile of autoantibodies directed against nuclear & cytoplasmic antigens.

Unpredictable disease.

Systemic vasculitis with immune complex deposition.

Question 6

How is SLE diagnosed?

Answer 6

positive DIF
linear deposits of IgG or IgM and/or C3
CD4+ T lymphocytes also present.

Question 7

What are the oral manifestations of SLE?

lupus

Answer 7

• whitish plaque with erythema or erosive lesion in the center and keratotic striae in the periphery
• telangiectasia (small red/purple capillary clusters, spidery appearance) on lips, buccal mucosa and gingiva
• red mucosal macules and plaques, mucosal ulcers and lesions resembling lichen planus
• recurrent aphthous stomatitis and oral ulcers