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MYCOLOGY & VIROLOGY > Systemic Mycoses > Flashcards

Systemic Mycoses Flashcards

(58 cards)

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1
Q

What part/s of the body does systemic mycoses invade?

A

Deep organs

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2
Q

Two groups under systemic mycoses

A

Endemic, opportunistic

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3
Q

What does GAFFI mean?

A

Global Action Fund for Fungal Infections

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4
Q

Systemic mycoses is transmitted through ______

A

Inhalation

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5
Q

Fungi can be isolated from?

A

Acidic soil or soil mixed guano

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6
Q

Modified true or false:

Fungi can survive in the lungs thru evolving outside the host

A

False. Inside the host

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7
Q

What are the thermally dimorphic mycoses that falls under systemic mycoses

A

Blastomycosis
Coccidioidomycosis
Histoplasmosis
Paracoccidioidomycosis
Talaromycosis
Emergomycosis

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8
Q

What form do thermally dimorphic fungi take under 30°C?

A

Mold form

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9
Q

What form do thermally dimorphic fungi take at body temperature?

A

Yeast form

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10
Q

Causative agent of blastomycosis

A

Blastomyces dermatitidis

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11
Q

Blastomycosis is endemic in?

A

USA
Canada
Manitoba
Africa
India

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12
Q

Causative agent of Coccidioidomycosis

A

Coccidioides immitis/posadasii

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13
Q

Causative agent of Histoplasmosis

A

Histoplasma capsulatum

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14
Q

Causative agent of Paracoccidioidomycosis

A

Paracoccidioides brasiliensis

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15
Q

Paracoccidioidomycosis is endemic in?

A

South America

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16
Q

Causative agent of Talaromycosis

A

Talaromyces marneffei

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17
Q

Talaromycosis is endemic in?

A

South Asia
China

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18
Q

Causative agent of Emergomycosis

A

Emergomyces spp.

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19
Q

Blastomycosis can be characterized by:

A

Granulomatous and suppurative lesions

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20
Q

What does Blastomyces dermititidis prefer to infect:

A

Skin & bones

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21
Q

What does Blastomyces dermititidis look like under the microscope in a tissue biopsy

A

Large, spherical, thick-walled budding yeast

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22
Q

Antigens present in B. dermititidis

A

Blastomycin
Antigen A
BAD-1

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23
Q

What immunodominant motif does B. dermatitidis have?

A

Blastomyces Adhesin-1

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24
Q

Signs and symptoms of Blastomycosis

Study These Flashcards
A

Fever
Malaise
Night sweats
Cough
Myalgias
Chronic Pneumonia

25
In patients with Pneumonia in Blastomycosis, what can be found on histological exam?
Pyogranulomatous reaction w/ neutrophils Noncaseating granulomas
26
Other than the common etiologic agents, what are the other causes of Blastomycosis?
B. helicus B. percursus B. emzantsi
27
Where can the mycelial forms of Blastomyces be found in the environment?
Wooded land w/ damp soil near water
28
Colony appearance of Blastomyces in SDA, and in microscope
White or brownish colony Branched hyphae w/ spherical conidia on lateral conidiophores
29
Coccidioidomycosis is also known as
San Joaquin Valley fever Valley fever
30
What are the common agents of Coccidioidomycosis?
Coccidioides Immitis C. Posadasiii
31
How are the common agents of Coccidioidomycosis be differentiated? Why?
Genotyping and Phylogenetic analysis They are phenotypically indistinguishable
32
Colony appearance of Coccidioides, and appearance under the microscope
White to tan colony Hyaline septate hyphae forming arthtroconidia
33
Appearance of Coccidioides after inhalation
Large, thick-walled spherules with endospores - mature Thick-walled spherules with clear center - young
34
Antigenic structures present in Coccidioides
Coccidioidin Spherulin
35
An antigen produced from a filtrate of a broth culture of spherules in Coccdioidomycosis
Spherulin
36
Test used to check for Coccidioidomycosis, and its result
Skin test Delayed positive skin test using Coccidioidin & spherulin
37
Coccidioidomycosis is common among:
Males Pregnant women Immunocompromised people
38
Culture media used for Coccidioides immitis/posadasii
Inhibitory Mold Agar (IMA) slants Or Blood-Hear Infused Agar (BHIA) slants W/ or w/o antibiotics & cyclohexamide @30°C or 37°C
39
Serological tests in identifying Coccidioidomycosis
Latex agglutination test ID or CF test Coccidioidin skin test Spherulin skin test
40
Treatment used for Coccidioidomycosis
Ampothericin B Itraconazole
41
Where can Coccidioides be isolated from?
Desert soils
42
The most prevalent pulmonary intracellular mycosis worldwide
Histoplasmosis
43
Histoplasmosis caused by Hc is also known as
Darling's disease
44
What animals can Histoplasmosis be associated with?
Birds and bats
45
What variant in humans of H. capsulatum resembles TB
H. capsulatum var. capsulatum
46
H. capsulatum variant that causes skin and bone lesions
H. capsulatum var. duboisii
47
What variant of H. capsulatum causes lymphangitis in horses?
H. capsulatum var. Farciminosum
48
What is the gold standard for testing Histoplasmosis
Culture
49
Colony appearance of Histoplasma
White suede front Pale yellow brown reverse
50
Morphology of Histoplasma
Hyaline, septate hyphae produce microconidia & thick-walled macroconidia w/ peripheral projections
51
Antigen found in Histoplasmosis
Histoplasmin
52
Laboratory tests used for diagnosing Histoplasmosis
CF test ID test RA / EIA
53
Modified true or false: When Histoplasmosis have disseminated, there is a high chance of death if it's left untreated with antifungal therapy
True
54
How to confirm growth of Histoplasmosis?
In-vitro conversion to yeast form
55
A mycoaes that presents as a chronic granulomatous disease that produces primary pulmonary infection
Paracoccidioidomycosis
56
Mode of transmission for Talaromyces marneffei
- Traumatic implantation - Eating of bamboo rats - Inhalation of spores near bamboo rat burrows
57
Talaromycosis is associated with what animal?
Bamboo rats
58
Colong appearance of Talaromyces
Green-yellow colony w/ diffusable reddish pigment

MYCOLOGY & VIROLOGY (7 decks)

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