Systemic Skin Manifestations

Question 1

What is this condition and what organ/system is involved

Answer 1

jaundice (liver)

Question 2

what is this condition and what organ/system is involved

Answer 2

caput medusae (liver)

Question 3

what is this condition and what organ/system is involved

Answer 3

palmar erythema (liver)

Question 4

What is this condition and what organ/system is involved

Answer 4

Muehrcke Nail (liver)

Question 5

What is this condition and what organ/system is involved

Answer 5

Terry’s nail (liver)

Question 6

What is this condition and what organ/system is involved

Answer 6

Lindsay’s nail (renal)

Question 7

what is this condition and what organ/system is involved

Answer 7

calcinosis cutis (renal/thyroid)

Question 8

What is this condition and what organ/system is involved

Answer 8

calciphylaxis (renal)

Question 9

What is this condition and what organ/system is involved

Answer 9

Thyroid dermopathy (endocrine - thyroid)

Question 10

What is this condition and what organ/system is involved

Answer 10

Cushing’s Syndrome (Endo - adrenal)

Question 10

What is this condition and what organ/system is involved

Answer 10

Hirsutism (endo - adrenal (also PCOS))

Question 10

What is this condition and what organ/system is involved

Answer 10

Adrenal insufficiency (Endo - adrenal)

Question 11

What is this condition and what organ/system is involved

Answer 11

Diabetic dermopathy (endo - pancreas)

Question 12

What condition is this and what organ/system is involved

Answer 12

Diabetic thick skin (endo - pancreas)

Question 13

What condition is this and what organ/system is involved

Answer 13

acanthosis nigricans (endo - pancreas)

Question 14

What condition is this and what organ/system is involved

Answer 14

Rheumatoid Arthritic Nodules

Question 15

What condition is this and what organ/system is involved

Answer 15

Rheumatoid arthritic vasculitis

Question 16

What condition is this and what organ/system is involved

Answer 16

systemic lupus erythematosus (rheum)

Question 17

What condition is this

Answer 17

paget’s disease

Question 18

What condition is this

Answer 18

inflammatory breast cancer

Question 19

what condition is this

Answer 19

leukemia cutis

Question 20

etiology of leukemia cutis

Answer 20

dissemination of neoplastic leukocytes into subQ, dermis, and epidermis

Question 21

etiology of inflammatory breast cancer

Answer 21

rare, rapidly progressing, most commonly diagnosed at late stage

Question 22

Etiology of Paget’s disease

Answer 22

intradermal carcinoma of nipple

Question 23

Clinical presentation of systemic lupus erythematosus

Answer 23

**malar rash** - butterfly rash on face, spares intertriginous areas discoid rash vasculitis seen in 20% of pts 80% of pts have mucous involvement

Question 24

etiology of rheumatoid arthritis nodules and vasculitis

Answer 24

presents late in disease

Question 25

etiology of acanthosis nigricans

Answer 25

hyperinsulin state activates insulin growth receptors on keratinocytes provoking proliferation into the epidermis

Question 26

etiology of diabetic thick skin

Answer 26

buildup of sugar alcohols in upper dermis leading to stiffening of collagen

Question 27

etiology of diabetic dermopathy

Answer 27

may be caused by trauma, hemosiderin, melanin deposition, and change to blood vessels or dermis

Question 28

etiology of adrenal insufficiency

Answer 28

low cortisol leading to high ACTH leading to high melanocyte stimulating hormone leading to excess melanin synthesis

Question 29

Etiology of hirsutism

Answer 29

excessive terminal hair growth in a male pattern d/t excess adrogen sex steroid

Question 30

etiology of cushing's syndrome

Answer 30

hypercortisolism from endogenous or exogenous (glucocorticosteroids)

Question 31

etiology of diabetic dermopathy

Answer 31

late manifestation of Grave's Disease buildup of carbs/proteins in dermis and subQ

Question 32

etiology of calciphylaxis

Answer 32

end stage renal disease abnormal calcification of arterioles in dermis, subQ, adipose tissue resulting in formation of fibrosis, thrombi, ischemia leading to NECROSIS

Question 33

etiology of calcinosis cutis

Answer 33

seen with hyperparathyroidism, Ca and Ph mobilized from bone to serum and deposited in skin

Question 34

etiology of Lindsay's nails

Answer 34

increased concentration of melanocyte stimulating hormone

Question 35

etiology of Muehrcke and Terry Nails

Answer 35

hypoalbuminemia and edema

Question 36

etiology of palmar erythema

Answer 36

altered sex hormone metabolism

Question 37

etiology of caput medusae

Answer 37

portal hypertension - blood shunted from liver to recannulated umbilical and abdominal wall veins

Question 38

etiology of jaundice

Answer 38

bilirubin/bile salts deposit in skin (itchy) due to dysfunction in the way it is processed and excreted through the body