t3 Flashcards
(38 cards)
robert hooke and cells
what year?
what did he do?
year : 1665
he built microscopes to examine thin sections of dried cork samples from plants - names cavities cells
cell theory
- all organisms are made up of cells
- the cell is the fundamental unit of life
- cells come from pre-existing cells
prokaryotic cells
prokaryotic cells lack a nucleus and have no internal compartmentalization
eukaryotes cells
eukaryotic cells have a nucleus and internal membrane-bound organelles
hopaniods
-located in membranes of bacteria
- modulate the fluidity of the membrane bilayer
-increase rigidity of the membrane
cholesterol
- found in animal cell membranes
- both polar and non polar regions
- impact membrane fluidity
all cells are defined by a cell man brand (lipids)
- lipids found in the cell membrane are phospholipids
- phospholipids have a hydrophobic tail (non polar region) and hydrophilic head (polar region)
lipid structures micelle
formed by phospholipids with large bulky heads and a single hydrophobic tail
lipid structure bilayer
bilayers and liposomes are formed by phospholipids with small heads and 2 hydrophobic tails
lipid structure phospholipid
when in water phospholipid spontaneously form a liposome, wherein polar heads and non polar tails associate with one another in a bilayer
membranes
membranes are self-healing because they will spontaneously reform
membranes are a fluid mosaic
- lipids and proteins are found in the membrane, forming a mosaic
- pupils are able to move laterally within the membrane
- lipid movement is affected by the nature of the phospholipid tails
saturated vs unsaturated
- van der waals interactions between the fatty acid tails help stabilize the membrane
- bc these interactions are weak, membrane lipids are able to move in the plane of the membrane, thus membrane is fluid
cholesterol
- found in many animal cell membranes
- both polar and non polar regions
- impact membrane fluidity
cholesterol and fluidity
cholesterol acts like a “buffer” for membrane fluidity
proteins in the membranes: transporters and receptors
- transporters that move ions and molecules
- receptors that allow the cell to receive signals from the environment
proteins in the membrane: enzyme and anchors
- enzyme that catalyze chemical reactions in a cell
- anchors that attach to other proteins such as actins or cytoskeleton that help to maintain cell structure and shape
integral proteins
- integral membrane proteins are permanently associated with the membrane and can cross the entire membrane
peripheral proteins
- peripheral membrane proteins are temporarily associated with either side of the membrane
examples of integral membrane proteins
- sodium-potassium pump
- aquaporins
- ATP synthase
examples of peripheral membrane proteins
- cytochrome c
- phospholipase
glycolipid transfer proteins
evidence for the fluid mosaic model: is there movement in the membrane?
- proteins are fluorescently labeled
- one specific region of the membrane is targeted by a laser and photo bleached
- researchers than observe the membrane to see if the bleached area remains, or if fluorescent proteins return to the bleached area
protein ls do move in the membrane
- fluorescence returns to the bleached area, showing that proteins are mobile throughout the membrane
cell membranes
- the cell to the right is a pancreatic cell. the cell is surrounded by a cell membrane which defines the shape and size of the cell