Table Review of Endocrine causes of PU/PD Flashcards
Central DI results in lack of what
ADH
How can you screen for central DI
Water deprivation test
Desmopressin test
What is mechanism of nephrogenic DI
Lack of response to ADH
How can you screen for nephrogenic DI
Water deprivation test
What test can you run to determine difference between central and nephrogenic DI
Exogenous ADH (VP)
Central- will respond, increase USG
Nephrogenic- no change
Cushing’ causes PU/PD by what mechanism and what other disorder is commonly associated with it
Hypercortisolemia antagonism to ADH receptor, secondary DI
How can you screen for Cushings
ACTH stim test
Low dose dex suppression test
How does pheochromocytoma cause PU/PD
Central DI
E2–> decreased ADH
How can you screen for pheochromocytoma
Elevated urine VMA
Adrenal tumor
How does hyperadolsteronism (conn’s syndrome) cause PU/PD
secondary DI, hypokalemia downregulates Aquaporin channels
How to screen for Conn’s syndrome
Elevated serum aldosterone, adrenal tumor
How does hyperthyroidism cause PU/PD
Medullary WO concurrent with chronic kidney disease
How can you screen for hyperthyroidism
Elevated T4, goiter
How does hyperparathyroidism cause PU/PD
Hypercalcemia, secondary DI
How can you screen for hyperparathyroidism
PTH (or PTHrp) and iCa2+ elevated
