TAD Overdose

Question 1

TAD Overdose Four Effects

Answer 1

Inhibition of noradrenalin reuptake, alpha adrenergic block, membrane stabilising effect on myocardium, anticholinergic action

Question 2

TAD Overdose Presentation

Answer 2

Affects peripheral autonomic nervous system, CVS, CNS

• Anticholinergic effects: dry mouth, blurred vision, dilated pupils, hyperthermia, delayed gastric emptying
• CV effects: Sinus tachycardia, (inhibition of noradrenalin uptake), myocardial stability; slowed depolarisation, wide QRS complexes and PR/QT intervals, hypotension
• CNS effects: Coma, seizures,

Question 3

TAD Overdose Management

Answer 3

Airway protection, activated charcoal (within 1 hour if airways secure), sodium bicarbonate, fluids, benzodiazepines for seizures, blood pH, ECG