TAI

Question 1

TAI means ?

Answer 1

Thrombocyte aggregation inhibitor

Question 2

2-thrombocyte aggregation happening ?

Khodesho dare mige na aminhibitionesh

Answer 2

• formation of the white thrombus - closure of the blood vessel.
• thrombin release
• contraction phase

Question 3

3-Coagulation mechanism 3

Answer 3

1st phase - release of thromboplastin
• 2nd main phase - coagulation
• 3d phase - contraction of coagulum

Question 4

4- Indication of antithrombotic drugs administration
Arterial thrombosis prevention.

Answer 4

Question 5

5-TAI drugs orally ?

Answer 5

Question 6

Answer 6

Question 7

Pt test is for … pathway and in card 6 we have explained that
Appt test full name is … nad for … pathwat

Answer 7

Extrinsic (should be between 12-15 sec)

Activated partial thromboplastin time

Intrinsic

Question 8

Lecture ghabl
New generation drug name orally was for exp RIVAROXA was dirrectly affect and inhibit factor 10a (Xa)
So last semester oral bio ham hamino goft4 bood .
Pas ina hame AT hastand

Answer 8

Question 9

TAI - Acetylsalicylic acid

Answer 9

Question 10

Aspirin therapy in high rist and losr risk cardio vascular patient ?

Answer 10

Tasavor kon ye adame moztarwb (high risk ) mikhabe amal kone aspirino mikoni too dahanesh 😂

Question 11

Fekonam faghat in 3 ta

TA clo-idogrol tricagrelor prasugrel are … and … inhibitor ?

Answer 11

Thrombocyte adenosine-diphosphate(ADP) inhibitors
Kry:
TAI be jaye A (ADP) bezar mesle riazii

P2Y12 receptor irreversible inhibition.

Question 12

when Suspension of drug
And retake of drug ?

Answer 12

Drug therapy should be suspended before surgical treatmen

Key:kollan khalaf mamnoo
Hala lorhaye club boro 5 rooz
Sugera 5-7 rooz

5 days before (Clopidogrel, Tricagrelor),

5-7 days before(Prasugrel)
Retake of the drug should be started 24-48 hours after the treatment

Key: aspirin was 12 h agter

Question 13

Dual TAI treatment ?

Answer 13

Acetylsalicilic acid +
Clopidogrel/Tricagrelor/Prasugrel

Question 14

Indication of Dual TAI treatment ?

عاشوريان

Answer 14

6 mah diual badesh kamesh mikonim taki

Indication:
acute coronary syndrome, a c s (AMI ASHORIAN )
stent surgery s s
consult with treating physician
• Suspension of one of the TAI drug

Question 15

Answer 15

Consult with treating physician, drug intake should suspended 1-2
days prior to the treatment
• Drug intake should be restarted 24 hours after the intervention

Question 16

Answer 16

Dipyridamole: vasodilator
• Cilostazol: phosphodiesterase 3 inhibitor
• Reversibly inhibit Thrombocyte aggregation. The effect depends on the half-life of the drug
• half-life: Dipyridamole 10 hours / Cilostazol 11-13 hours

Question 17

Local hemostssis .?

Answer 17

Compression
• Tamponade, closure (with flap)
• Absorbents (Spongostan, Gelaspon, Surgicell)
• Sutures
• Tissue glues
• Dicynone
OBSERVATION

Key:
Mark tyson (no)
dyson (no)
di30none(yes)

Question 18

Answer 18

Tissue glues: چسب ٢ قلو 1-2a
• Fibrinogen-thrombin containing2component substances
• Exp.:Beriplast,TISSELLYO,Evicel
• Indication:hemostasis,woundhealing,tissue union

Key:
Factor 1 va factor 2a (fibrnogen-theombin)

Key: raftam PLAZA didam Lio onjast (sag) Eveen Ham didam

Key: indication ha 2 tash titre darsie

Question 19

Dicynone

Other name .?
3 main imp function .?
Tablet is …. .
…. Before precidure … tablet.
…. Tablet after surgary and repeat … hour if neccesary

Injection .?

Answer 19

Vaghti migi
Ee tom laye paye khodeto niga kin
Ee tom see lat