Targeted Cancer Drugs

Question 1

Imiquimod MOA

Answer 1

1. Activates TLRs
2. Blocks adenosine receptor
3. Activates NFkB –> upregulation of cytokines like TNF-alhpa and ILs
   HEDGEHOG!!

Question 2

Administration of Imiquimod?

Answer 2

Topical

Question 3

What does Imiquimod like… do?

Answer 3

Initiates immune response to fight small tumors

Question 4

Imiquimod ADE?

Answer 4

1. Allergic skin reactions
2. Photosensitivity
3. Can compromise condom and diaphragm integrity
4. Pregnancy category C

Question 5

Imiquimod treats

Answer 5

BCC, actinic keratosis, HPV

Question 6

Vismodegib MOA

Answer 6

SMO inhibitor

Question 7

Vismodegib administration

Answer 7

oral

Question 8

Vismodegib ADE

Answer 8

1. Intrauterine fetal death
2. Male mediated teratogenicity
3. Pregnancy- male and female pts need to practice contraception
4. Alopecia
5. GI toxicity

Question 9

Vismodegib treats

Answer 9

BCC

Question 10

Aldesleukin MOA

Answer 10

Binds to IL-2 receptor –> induces proliferation of B and T cells, monocytes, macrophages, CTLs

Question 11

Aldesleukin ADE

Answer 11

Everything

Question 12

Aldesleukin treats

Answer 12

Melanoma

Question 13

Interferon-alpha 2b (IV or SC) MOA

Answer 13

Antiviral AND Antineoplastic

1. Promotes cell cycle arrest in G0
2. Induces apoptosis
3. Induces immune response

Question 14

Interferon-alpha 2b ADE

Answer 14

Liver, Pulm, CV, CNS

Question 15

Interferon-alpha 2b treats

Answer 15

Melanoma

Question 16

Ipilimumab MOA

Answer 16

CTLA-4 antibody–> Bolsters anti-tumor response of immune system

Question 17

Ipilimumab ADE

Answer 17

Endocrinopathies

Question 18

Ipilimumab treats

Answer 18

Melanoma

Question 19

Sorafenib MOA

Answer 19

Oral multi-kinase inhibitor for VEGF, PDGFR, Raf kinase

1. Targets RAF/MEK/ERK pathway –> inhibits tumor proliferation
2. Targets VEGFR-2 & PDGFR –> inhibits angiogenesis

Question 20

Sorafenib ADE

Answer 20

Liver, Lungs (bleed), HTN

Question 21

Sorafenib treats

Answer 21

Melanoma

Question 22

Trametinib MOA

Answer 22

Oral reversible MEK inhibitor

Question 23

What mutations are necessary for treatment with Trametinib?

Answer 23

BRAF V600E or V600K (must test for these mutations before beginning treatment)

Question 24

Trametinib ADE

Answer 24

Lungs, CV, Eyes

Question 25

Trametinib treats

Answer 25

Melanoma

Question 26

Vemurafenib MOA

Answer 26

Oral inhibitor of mutated BRAF (BRAF V600E)

Question 27

Vemurafenib ADE

Answer 27

Liver, CV, eyes

Question 28

Do you need to genotype the pt before tx with Vemurafenib?

Answer 28

YES!!

Question 29

Vemurafenib treats?

Answer 29

Melanoma

Question 30

What are 2 treatments for actinic keratosis?

Answer 30

Diclofenac and Trichloroacetic acid

Question 31

Diclofenac MOA

Answer 31

Inhibits PGE2 (inflammatory mediator)

Question 32

Trichloroacetic acid MOA

Answer 32

Chemical peel; rapidly penetrates and cauterizes skin, keratin, and other tissue

Question 33

What is the only drug on the list that treats SCC?

Answer 33

Cisplatin

Question 34

What all drugs can treat actinic keratosis?

Answer 34

Imiquimod, Fluorouracil, Diclofenac, Trichloroacetic acid

Question 35

What targeted cancer therapies can cause a rash?

Answer 35

Imiquimod, Ipilimumab, Sorafenib, Trametinib, Vemurafenib | *Acronym VISIT

Question 36

What drugs treat BCC

Answer 36

Cyclophosphomide, Cisplatin, Imiquimod, Vismodegib