Targeted Therapy Flashcards by Amy Johnson

Target validation process

causal relation b/w target and disease
has to do with:
1. specificity
2. affinity
3. mode of action (short term vs long term)
4. regulation of effects

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dose-effect relationship

quantitative

at individual level

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dose-response relationship

quantitative
at group level (how many pts responded in a group?)
most drugs use this

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Biomarkers for selection in cancer therapy= EGFR

Erlotinib (lung cancer)

Cetuximab (colon cancer)

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MammaPrint

validated for breast cancer pts
predict risk of distant metastasis
aggressive tx can be considered in pts with poor prognosis

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DPD (dihydroprimidine dehydrogenase)

enzyme that breaks down 5-FU

aberrant methylation of DPYD promoter causes DPD deficiency

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Thymidylate synthase (TS)

target for 5-FU

overexpression is linked to drug resistance

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Targeted Therapy Flashcards

(7 cards)