Targeting Microtubules

Question 1

Function of Vinca alkaloid

Answer 1

From periwinkle leaves that binds tubulin and prevent microtubule assembly.

Question 2

Type and vinca alkaloid and their toxicity

Answer 2

Vincristine(neurotoxic on axonal transport) and Vinblastine (myelosuppression affects bone marrow)

Question 3

Taxanes

Answer 3

From pacific yew tree which promote microtubule assembly and inhibit disassembly

Question 4

Abraxane

Answer 4

Taxane that is in form of paclitaxel in albumin-coated nanoparticles.

Question 5

Eoposide

Answer 5

Anti-tumor antibiotics which inhibit topoisomerase I and II so that DNA is broken down, but not re-constructed.

Question 6

Doxorubicin

Answer 6

Anthracycline which inhibits topoisomerase II and intercalate DNA to block DNA and RNA synthesis

Question 7

Problem of Doxorubicin

Answer 7

Alters cell membrane fluidity and ion transport, Free radical generation, and bone marrow and cardiac toxicity.

Question 8

Bleomycin

Answer 8

Cause DNA single and bouble strand breaks, and forms free radicals to inhibit DNA synthesis. Accumulate in G2.

Question 9

Family of drugs that targes microtublues

Answer 9

Vinca alkaloids and Txanes

Question 10

Family of drugs are anti-tumor antibiotics

Answer 10

Topoisomerase inhibitor(etoposide), Anthracycline, and Bleomycin