TB

Question 1

High level isoniazid resistance in a TB patient denotes a mutation in which gene

Answer 1

Kat G gene

Question 2

Low level isoniazid resistance in a patient with TB denotes a mutation in which gene

Answer 2

INH A gene

Question 3

A patient with TB does PCR testing to see the drug that he is sensitive to,
PCR reveals a mutation in RPO B gene
This means that the patient is resistant to which drug?

Answer 3

Rifampicine

Question 4

Culture of Mycobacteria TB takes….. To show results
But mycobacteria growth indicator tube(MGIT) takes….. To show results

Answer 4

. 6 weeks
. 2 weeks

Question 5

In radiometric technology (bactec 460), a growth index of….. Indicates presence of TB infection.

Answer 5

GI>10

Question 6

Adenosine Deaminase Test in CSF analysis indicates TB meningitis if its level is……

Answer 6

> 8 U/L

Question 7

Adenosine Deaminase Test in peritoneal fluid shows TB if its level is higher than…..

Answer 7

> 36 U/L

Question 8

In TB Meningitis,
. Switch from ethambutol to…..
. Duration of Tx is….. Instead of 6 m.
. ……. Should be used

Answer 8

. Streptomycin
. 9 to 12 months
. Steroids

Question 9

If Pt. Has HIV and TB and CD4 is <200,
When should antiretroviral Tx be started?

Answer 9

After 2-8 weeks of starting anti-TB drugs

Question 10

A pt. With TB has been taking anti TB drugs and cutaneous reactions occured, what is the most likely drug responsible for these cutaneous reactions.?
. Streptomycin
. Thiacetazone
. INH

Answer 10

. Thiacetazone

Question 11

A pregnant lady has TB, what is the anti TB drug that should not be used?
Why?

Answer 11

. Streptomycin
. Because it is ototoxic to the fetus

Question 12

True or false
First line anti TB drugs are not safe to be used in pregnancy

Answer 12

False
They are safe except streptomycin

Question 13

Streptomycin dose shoupd be reduced if renal creat clearance is less than…..

Answer 13

50 ml/min