TB drugs Flashcards
(16 cards)
MOA of Isoniazid
Inhibition of mycolic acid synthesis through enoyl -ACP reductase of FA synthase II
MOA of Rifamycin
Inhibition of transcription by binding to and interfering with RNA dependent DNA polymerase
MOA of Pyrazinamide
Inhibition of membrane transport and reduction of intracellular pH
MOA of Rifamycin
Inhibition of arabinosyl transferase involved in cell wall synthesis
MOA of Streptomycin
Inhibition of translation by binding to 30s ribosomal subunit
Kinetics of isoniazid
Readily absorbed via oral/parenteral intake
Widely distributed in all body cells and fluids
75-95% excreted in urine w/in 24 h
Isoniazid is excreted as
Excreted as acetylisoniazid and isonicotinic acid
Function of pyridoxine in TB medication
Minimizes toxic effects of isoniazid; 10mg daily dose for prevention of side effects, 50-100mg for treatment
Adverse effects of isoniazid
Rash, fever, hepatotoxicity, peripheral neuritis(main), convulsions, optic neuritis
Activated form of isoniazid
Nicotinoyl radical
Anti-TB drug that interacts with anti-seizure drugs in children
Isoniazid
Bactericidal for both intracellular and extracellular microbes
Rifamycins
Kinetics of rifamycins
Intestinal reabsorption is reduced by deacetylation and food
Adverse effect of rifamycin
Turns sweat, tears and urine into orange-red (pink) in color
Flu-like symptoms (fever, chills, myalgia)
Increased risk of severe hepatitis in pt w/chronic liver disease, alcoholism, and old age
Rash, nausea, vomiting
TB prophylaxis
Isoniazid
Prophylactic use of rifamycins
Meningococcal disease by H.influenzae
With beta-lactams and vancomycin against staphylococcal endocarditis or osteomyelitis
