TBL #1 Flashcards
The only drug in the antimetabolites class that does NOT cause myelosuppression is: A. 5-Fluorouracil (5-FU) B. Fludarabine C. Capecitabine D. Gemcitabine E. Methotrexate
C. Capecitabine
Which 2 drugs are the only drugs that can cause hand-foot syndrome?
A. 5-Fluorouracil (5-FU) and capecitabine
B. Fludarabine and 5-FU
C. Capecitabine and gemcitabine
D. Gemcitabine and pemetrexed
E. Methotrexate and capecitabine
A. 5-Fluorouracil (5-FU) and capecitabine
Deficiency of DPD (dihydropyrimidine dehydrogenase) correlates with increased toxicity of this drug: A. 5-Fluorouracil (5-FU) B. Fludarabine C. Capecitabine D. Gemcitabine E. Methotrexate
A. 5-Fluorouracil (5-FU)
Which of the following medications can cause conjunctivitis with high dose and therefore requires steroid eyedrops while the patient is on treatment and 48 hours post-treatment? A. Pemetrexed B. Docetaxel C. Cytarabine D. Gemcitabine E. Methotrexate
C. Cytarabine
Which of the following alkylating agents have a high risk of hemorrhagic cystitis and therefore require simultaneous administration of mesna to the patient? A. Bendamustine and ifosfamide B. Cyclophosphamide and ifosfamide C. Bendamustine and cyclophosphamide D. Cisplatin and cyclophosphamide E. Carboplatin and cisplatin
B. Cyclophosphamide and ifosfamide
Bendamustine administered with ______ may increase the risk for Stevens-Johnson’s Syndrome.
Allopurinol
Hemorrhagic cystitis is an adverse effect that results from the use of cyclophosphamide and ifosfamide. This adverse effect results from the formation of a byproduct called _______.
Acrolein
For patients on cisplatin, due to the high risk of nephrotoxicity, patients should take _____ simultaneously or be switched to _____, which is much less renally toxic.
Amifostine
Carboplatin
A monitoring parameter for bendamustine is signs of dermatologic toxicity because bendamustine can cause dermatologic reactions, the most serious of which is called ______.
Stevens-Johnson’s Syndrome
Hydration is required with which three of the following alkylating agents? A. Cisplatin B. Bendamustine C. Carboplatin D. Cyclophosphamide E. Ifosfamide
A. Cisplatin
D. Cyclophosphamide
E. Ifosfamide
Which of the following alkylating agents can cause peripheral neuropathies that, if it lasts longer than 14 days, can be permanent? A. Carboplatin B. Oxaliplatin C. Cisplatin D. Ifosfamide E. Bendamustine
B. Oxaliplatin
Carboplatin is renally dosed using the ______ equation.
Calvert equation (Dose = AUC + (GFR + 25) NOTE: GFR capped at 125
The main adverse effect of oxaliplatin is _________.
Peripheral neuropathy
The main adverse effect of bendamustine is ________.
Dermatologic reactions (including Steven-Johnson’s Syndrome)
True or False: Carboplatin causes thrombocytopenia and hypersensitivity reactions at high cumulative doses.
True
True or False: Cisplatin causes myelosuppression.
False (However, anemia can be seen with chronic dosing)
Cisplatin can cause wasting of which 2 electrolytes? A. Calcium and Potassium B. Potassium and Magnesium C. Magnesium and Sodium D. Sodium and Calcium
B. Potassium and Magnesium
Amifostine and hydration are given with the administration of this chemotherapy agent.
Cisplatin
