Flashcards in TBL 5: HCV Deck (10):
What factors contribute to a higher prevalence of liver disease in AI/AN populations than non-indigenous populations?
ACCESS: lack of healthcare professionals (needing gastroenterologist & transportation) was a bigger deal than risky behavior
Inability to administer treatments:
How is HCV transmitted?
IV drug usage
blood transfusions prior to 1990
How is HCV diagnosed?
ELISA Anti-HCV antibody, or RNA genome detection via RT-PCR (GOLD STANDARD)
What HCV drug is teratogenic?
What HCV drug should be avoided w/ people who have liver cirrhosis?
How does IFN alpha work?
How does ribivarin work?
Ribonucleic analog: inhibits viral RNA pol and protein synth
booster for other drug concentrations by inhibiting CYP3A4(protease inhibitors are metabolized by CYP3A4, so ritonavir increases their concentration)
*causes increased hemolysis> increased bilirubin
What is ABT 450?
is an acylsulfonamide inhibitor of the NS3-4A serine protease
What is ombitasvir?
targets non-structural protein 5A, which normally is responsible for allowing replication of HCV and is a key regulator in cell function