TCA cycle and electron transport chain Flashcards Preview

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Flashcards in TCA cycle and electron transport chain Deck (21)
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1
Q

What happens in the first stage of the TCA cycle?

A

Oxaloacetate is converted to citrate
By citrate synthetase
Addition of acetyl coA

2
Q

What happens in the second stage of the TCA cycle?

A

Citrate is converted to cis aconitate
By aconitase
H2O lost

3
Q

What happens in the third stage of the TCA cycle?

A

Cis aconitate is converted to isocitrate

By aconitase

4
Q

What happens in the fourth stage of the TCA cycle?

A

Isocitrate is converted to alpha-keto glutarate
By isocitrate dehydrogenase
CO2 is lost
NAD+ becomes NADH

5
Q

What happens in the fifth stage of the TCA cycle?

A

Alpha-keto glutarate is converted to succinyl coA
By alpha-keto glutarate dehydrogenase complex
CO2 is lost
NAD+ becomes NADH

6
Q

What happens in the sixth stage of the TCA cycle?

A

Succinyl coA is converted to succinate
By succinyl coA synthetase
GDP becomes GTP

7
Q

What happens in the seventh stage of the TCA cycle?

A

Succinate is converted to fumarate
By succinate dehydrogenase
FAD becomes FADH2

8
Q

What happens in the eighth stage of the TCA cycle?

A

Fumarate is converted to malate
By fumarase
Addition of H2O

9
Q

What happens in the ninth stage of the TCA cycle?

A

Malate is converted to oxaloacetate
By malate dehydrogenase
NAD+ becomes NADH

10
Q

What is the net yield of ATP per molecule of glucose?

A

36

11
Q

Where does the electron transport chain take place?

A

Inner mitochondrial membrane

12
Q

How many membrane bound complexes are involved in ETC?

A

4

13
Q

How many mobile e- carriers are involved in the ETC?

A

2
Coenzyme Q
Cytochrome C

14
Q

How many ATP does NADH yield?

A

3

15
Q

How many ATP does FADH2 yield?

A

2

16
Q

How is energy used to make ATP?

A

Energy from electron transport chain drives efflux of H+ from mitochondrial matrix
Proton electrochemical gradient is created
ATP synthesis by ATP synthase

17
Q

Where is pyruvate converted to acetyl coenzyme A?

A

In the mitochondrial matrix

18
Q

What converts pyruvate to acetyl coA?

A

Pyruvate dehydrogenase complex

19
Q

What is the pyruvate dehydrogenase complex?

A

5x10^6 Da
60 polypeptide chains
Three enzymes

20
Q

What is the equation for pyruvate to acetyl coA?

A

Pyruvate + coA + NAD+
to
Acetyl CoA + CO2 + NADH

21
Q

What is beriberi and what is its cause?

A

Weakness and fatigue
Vitamin B1 deficiency
B1 needed for PDHC